Development of a Scalable and Safe Procedure for the Production of (3R)-3-(2,3-Dihydro-1-benzofuran-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]- quinolin-9-one, an Intermediate in the Synthesis of PDE-V Inhibitors RWJ387273 (R301249) & RWJ444772 (R290629)

Author(s): Bert Willemsens, Ivan Vervest, Dominic Ormerod, Wim Aelterman, Christine Fannes, Narda Mertens, István E. Markó, and Sebastien Lemaire

Date: 12/07/2006

Product(s) used