Biotage Endeavor replacement

Replace it with the H.E.L ChemSCAN — parallel high-pressure catalyst screening without the 7 mL and 40 bar ceilings

The Biotage® Endeavor™ has been discontinued. If you run one, the question is no longer how it compares — it is what replaces it, and whether you take the chance to lift the limits you have been working around. The ChemSCAN keeps the parallel, gas-uptake workflow your team already knows, and removes the ceilings.

Common reasons labs look at a replacement

Planning ahead

The Endeavor is no longer sold as a new instrument, so labs running one are increasingly working out what comes next as budgets and capital plans are set.

Consumables

The glass liners are made specifically for the Endeavor rather than being a standard catalogue item, which some labs weigh up when planning further ahead.

Room to grow

If your work now calls for more than 7 mL or 40 bar, sampling during a run, or active cooling, those are set by the design — so reaching them means a different platform.

Specification comparison

Specification Biotage Endeavor H.E.L ChemSCAN
Reactor zones 8 4 or 8
Working volume 1 – 7 mL
1 – 5 mL, blade impeller		 3 – 400 mL
from 2 mL on the ChemSCAN+
Reactor vessel sizes Fixed glass liners 16 – 500 mL
Maximum pressure 40 bar (600 psi) 100 bar (200 bar optional)
Temperature range Up to 200 °C Ambient – 200 °C
Active cooling None — 200 °C to ambient takes a couple of hours −40 °C option with circulator
In-run sampling Not available Sampling port option
Liquid dosing Not offered Optional, 0.02 – 40 mL/min
Vessel material Glass liners, custom-made for Biotage SS316 or Hastelloy HC276
Gas feed control Individual pressure transducer and gas valve per vessel Three feeds, inert and reactive, automatically controlled. Shared across the reactors, or independent to each reactor on the ChemSCAN+
Sensors Temperature and pressure Temperature, pH, DO, conductivity, redox
Analytical integration Data exported to tab-delimited text WinISO — GC-MS, HPLC and MS integration with feedback control

Working volumes go down to 3 mL in the 16 mL vessel, or 2 mL on the ChemSCAN+, depending on your chemistry and impellor choice. Speak to a specialist to confirm the lowest volume for your application.

Two rows go the other way. The Endeavor feeds each vessel individually, where the ChemSCAN uses a shared manifold with independent pressure measurement and control in every reactor — independent feeding and venting per reactor is available on the ChemSCAN+. And both reach 200 °C.

What you gain

From 7 mL to 400 mL

Endeavor tops out at 7 mL. The ChemSCAN runs 2 – 400 mL on one platform, so conditions found at screening scale are confirmed at working scale without changing instrument.

40 bar becomes 200 bar

Endeavor’s relief valve releases at 40 bar. The ChemSCAN runs to 100 bar as standard and 200 bar as an option — where much hydrogenation and carbonylation chemistry actually sits.

Sampling during the run

Endeavor has no sampling — you infer progress from gas uptake, or quench reactors at staggered times to imitate a time course. ChemSCAN vessels take a sampling port, so one experiment gives a real profile.

Cooling, not just heating

Endeavor has no active cooling; 200 °C to ambient is a couple of hours of passive decay. ChemSCAN reaches −40 °C with a circulator and controls the descent.

Hastelloy, not sole-source glass

ChemSCAN uses SS316 or Hastelloy C276 vessels rated to 200 bar and 350 °C — so corrosive and halide chemistry is in scope, and the consumable is not tied to one supplier.

Biotage Endeavor: frequently asked questions

Is the Biotage Endeavor discontinued?
Yes. The Biotage® Endeavor™ Catalyst Screening System is no longer sold as a new instrument. Existing units continue to run, but spares, service and the glass liners are worth confirming with Biotage before you plan around the platform long term.
What replaces the Biotage Endeavor?
The H.E.L ChemSCAN — a bench-top automated parallel reactor platform with real-time gas-uptake measurement, available in 4- and 8-reactor designs. It keeps the parallel screening workflow an Endeavor user already knows, and removes the 7 mL and 40 bar ceilings.
What is the maximum pressure of the Biotage Endeavor?
40 bar (600 psi). Biotage’s documentation states the pressure relief valve releases above 600 psi, and that supply gases should not exceed that figure. ChemSCAN runs to 100 bar as standard and 200 bar as an option.
What working volume does the Biotage Endeavor handle?
1 – 7 mL with the anchor impeller, or 1 – 5 mL with the blade type, depending on impeller and solvent viscosity. ChemSCAN covers 2 – 400 mL across vessels from 16 mL to 500 mL, so screening and scale-up happen on one platform.
How many reactors does the Biotage Endeavor have?
Eight, each physically separate with its own thermocouple, heater, pressure transducer and gas valve, and you only program the reactors you want to run. ChemSCAN offers 4- or 8-zone configurations with the same independence.
Can you take samples during a reaction on the Endeavor?
No. Biotage’s FAQ states there is no sampling — you monitor gas consumption to tell whether the reaction is working, or set reactors up identically and quench them at different times to imitate a time course. ChemSCAN vessels take a sampling port, so a single run gives a real profile.
Does the Biotage Endeavor have cooling?
No active cooling. It relies on small volume against a large steel reactor mass, and cooling from 200 °C to ambient takes a couple of hours passively. ChemSCAN reaches −40 °C with a circulator and controls the rate of descent.
Are Biotage Endeavor glass liners still available?
The liners are custom made for Biotage rather than a standard catalogue item, so they are a single-source consumable. On a platform that is no longer sold, that is worth checking before committing further work to the instrument. ChemSCAN uses SS316 or Hastelloy C276 vessels rated to 200 bar and 350 °C.
What is the difference between the Biotage Endeavor and the ChemSCAN?
Scale, pressure, sampling, cooling and vessel materials. Endeavor tops out at 7 mL and 40 bar with no sampling and no active cooling; the ChemSCAN runs 2 – 400 mL to 200 bar, takes a sampling port, and cools to −40 °C. The Endeavor does feed each vessel independently, which the ChemSCAN does through a shared manifold — independent feeding and venting per reactor is available on the ChemSCAN+.
Is the ChemSCAN a like-for-like Endeavor alternative?
For the parallel gas-uptake screening workflow, yes — and it removes the ceilings rather than reproducing them. Tell us the chemistry, the scale you need to reach and the pressure you run at, and we will confirm which ChemSCAN fits, or tell you if it does not.

Sources

Endeavor specifications: Biotage® Endeavor™ Frequently Asked Questions, part number PPS368, © Biotage 2015. ChemSCAN specifications: ChemSCAN brochure v1.9. Biotage® and Endeavor™ are trademarks of Biotage AB, used here only to identify the product being replaced. H.E.L Group is not affiliated with, endorsed by, or a distributor for Biotage AB.

Replacing an Endeavor?

Tell us the chemistry, the scale you need to reach and the pressure you run at, and we will tell you which ChemSCAN fits — or if it does not.

Ask a specialist