In industries ranging from pharmaceuticals to fine chemicals, scaling-up bench-top chemical reactions to production volumes carries a number of risks and challenges.
Central to the risks involved with scale-up are the changes in heat loss behavior with scale:
- Many reactions are exothermic and require cooling to ensure safe operation when performed on a large scale;
- Components in the reaction may become unstable under certain operating conditions, leading to additional thermal hazards.
- Identifying and mitigating risk sources during the process scale-up is necessary.
H.E.L Group has a range of solutions to help you identify and quantify thermal hazards at the laboratory scale, which support your process safety and scale-up requirements.