Biotage Endeavor replacement

Replace it with the H.E.L ChemSCAN range — parallel high-pressure catalyst screening without the 7 mL and 40 bar ceilings

The Biotage® Endeavor™ has been discontinued. If you run one, the question is no longer how it compares — it is what replaces it, and whether you take the chance to lift the limits you have been working around. The ChemSCAN family keeps the parallel, gas-uptake workflow your team already knows, and removes the ceilings.

Why replace your Endeavor

No new units are made

The Endeavor is discontinued. Spares, service and software support can only reduce from here, and an unsupported high-pressure instrument is hard to justify in a safety review.

Only Biotage makes the liners

Biotage’s own FAQ says the glass liners are “custom made for Biotage” — you cannot buy them anywhere else. On an instrument that is no longer made, that means when the liners run out, the instrument stops.

The limits cannot be raised

7 mL, 40 bar, no sampling and no cooling are built into the design. They are not settings you can turn up, and no upgrade raises them — so chemistry that outgrows them has to move to another instrument.

Specification comparison

Endeavor figures come from Biotage’s own published FAQ; ChemSCAN figures from ChemSCAN brochure v1.9.

Specification Biotage Endeavor ChemSCAN SA ChemSCAN ChemSCAN+
Reactor zones 8 4 or 8 4 or 8 4 or 8
Working volume 1 – 7 mL
1 – 5 mL, blade impeller		 3 – 400 mL 3 – 400 mL 2 – 400 mL
Reactor vessel sizes Fixed glass liners 16 – 500 mL 16 – 500 mL 16 – 500 mL
Maximum pressure 40 bar (600 psi) 100 bar (200 bar optional) 100 bar (200 bar optional) 100 bar (200 bar optional)
Temperature range Up to 200 °C Ambient – 200+ °C Ambient – 200+ °C 25 – 200 °C
Active cooling None — 200 °C to ambient takes a couple of hours −40 °C option with circulator −40 °C option with circulator −40 °C option with circulator
In-run sampling Not available Sampling port option Sampling port option Sampling port option
Liquid dosing Not offered Optional, 0.02 – 40 mL/min Optional, 0.02 – 40 mL/min Optional, 0.02 – 40 mL/min
Vessel material Glass liners, custom-made for Biotage SS316 or Hastelloy HC276 SS316 or Hastelloy HC276 SS316 or Hastelloy HC276
Gas feed control Individual pressure transducer and gas valve per vessel 2, shared, manually controlled 3, shared, automated 3, individual, automated
Sensors Temperature and pressure Temperature, pH, DO, conductivity, redox Temperature, pH, DO, conductivity, redox Temperature, pH, DO, conductivity, redox
Analytical integration Data exported to tab-delimited text WinISO — GC-MS, HPLC and MS integration with feedback control WinISO — GC-MS, HPLC and MS integration with feedback control WinISO — GC-MS, HPLC and MS integration with feedback control

Two rows are worth reading honestly. On gas feed control Endeavor already regulates each vessel individually, which puts it level with ChemSCAN+ and ahead of SA and ChemSCAN. On temperature both reach 200 °C. The case for replacing it rests on scale, pressure, sampling, cooling and materials — not on every line of the table.

What you gain

From 7 mL to 400 mL

Endeavor tops out at 7 mL. ChemSCAN+ runs 2 – 400 mL on one platform, so conditions found at screening scale are confirmed at working scale without changing instrument.

40 bar becomes 200 bar

Endeavor’s relief valve releases at 40 bar. ChemSCAN+ runs to 100 bar as standard and 200 bar as an option — where much hydrogenation and carbonylation chemistry actually sits.

Sampling during the run

Endeavor has no sampling — you infer progress from gas uptake, or quench reactors at staggered times to imitate a time course. ChemSCAN vessels take a sampling port, so one experiment gives a real profile.

Cooling, not just heating

Endeavor has no active cooling; 200 °C to ambient is a couple of hours of passive decay. ChemSCAN reaches −40 °C with a circulator and controls the descent.

Hastelloy, not sole-source glass

ChemSCAN uses SS316 or Hastelloy C276 vessels rated to 200 bar and 350 °C — so corrosive and halide chemistry is in scope, and the consumable is not tied to one supplier.

Which ChemSCAN replaces your Endeavor?

If… Choose Why
You want the closest like-for-like ChemSCAN+ Endeavor already gives every vessel its own gas valve, so ChemSCAN+ is the direct equivalent — three individual automated gas feeds, plus the scale, pressure and sampling Endeavor never had.
You mainly ran routine optimization ChemSCAN Automated, independent pressure control with three shared gas feeds. The right choice unless you genuinely fed reactors differently from one another.
You need the lowest-cost replacement ChemSCAN SA Independent temperature and stirring per zone with manual pressure profiling — still clears the 7 mL and 40 bar ceilings, at the lowest entry point.

All three run up to 8 zones and are customisable to your chemistry. If you are unsure which fits, tell us what you actually ran on the Endeavor and we will map it.

Biotage Endeavor: frequently asked questions

Is the Biotage Endeavor discontinued?
Yes. The Biotage® Endeavor™ Catalyst Screening System is no longer sold as a new instrument. Existing units continue to run, but spares, service and the glass liners are worth confirming with Biotage before you plan around the platform long term.
What replaces the Biotage Endeavor?
The H.E.L ChemSCAN family is the closest direct replacement: parallel high-pressure reactors with real-time gas-uptake measurement, in 4- and 8-zone configurations. ChemSCAN+ is the nearest like-for-like, because it gives every reactor its own automated gas feed, as the Endeavor did. ChemSCAN and ChemSCAN SA cover the same workflow at lower levels of automation.
What is the maximum pressure of the Biotage Endeavor?
40 bar (600 psi). Biotage’s documentation states the pressure relief valve releases above 600 psi, and that supply gases should not exceed that figure. ChemSCAN runs to 100 bar as standard and 200 bar as an option.
What working volume does the Biotage Endeavor handle?
1 – 7 mL with the anchor impeller, or 1 – 5 mL with the blade type, depending on impeller and solvent viscosity. ChemSCAN covers 2 – 400 mL across vessels from 16 mL to 500 mL, so screening and scale-up happen on one platform.
How many reactors does the Biotage Endeavor have?
Eight, each physically separate with its own thermocouple, heater, pressure transducer and gas valve, and you only program the reactors you want to run. ChemSCAN offers 4- or 8-zone configurations with the same independence.
Can you take samples during a reaction on the Endeavor?
No. Biotage’s FAQ states there is no sampling — you monitor gas consumption to tell whether the reaction is working, or set reactors up identically and quench them at different times to imitate a time course. ChemSCAN vessels take a sampling port, so a single run gives a real profile.
Does the Biotage Endeavor have cooling?
No active cooling. It relies on small volume against a large steel reactor mass, and cooling from 200 °C to ambient takes a couple of hours passively. ChemSCAN reaches −40 °C with a circulator and controls the rate of descent.
Are Biotage Endeavor glass liners still available?
The liners are custom made for Biotage rather than a standard catalogue item, so they are a single-source consumable. On a platform that is no longer sold, that is worth checking before committing further work to the instrument. ChemSCAN uses SS316 or Hastelloy C276 vessels rated to 200 bar and 350 °C.
What is the difference between the Biotage Endeavor and ChemSCAN+?
Scale, pressure, sampling, cooling and vessel materials. Endeavor tops out at 7 mL and 40 bar with no sampling and no active cooling; ChemSCAN+ runs 2 – 400 mL to 200 bar, takes a sampling port, and cools to −40 °C. On gas control they are comparable — both feed each reactor independently.
Is the ChemSCAN a like-for-like Endeavor alternative?
For the parallel gas-uptake screening workflow, yes — and it removes the ceilings rather than reproducing them. Tell us the chemistry, the scale you need to reach and the pressure you run at, and we will confirm which ChemSCAN fits, or tell you if it does not.

Sources

Endeavor specifications: Biotage® Endeavor™ Frequently Asked Questions, part number PPS368, © Biotage 2015. ChemSCAN specifications: ChemSCAN brochure v1.9. Biotage® and Endeavor™ are trademarks of Biotage AB, used here only to identify the product being replaced. H.E.L Group is not affiliated with, endorsed by, or a distributor for Biotage AB.

Replacing an Endeavor?

Tell us the chemistry, the scale you need to reach and the pressure you run at, and we will tell you which ChemSCAN fits — or if it does not.

Ask a specialist