Automated Crystalization Solutions

Our crystallisation systems enable controlled crystallisation process development, supporting nucleation control, crystal growth, polymorph screening, and scale-up for pharmaceutical and chemical manufacturing.

Why Choose Us?

Trusted by industry and academia, we deliver robust, practical solutions for real-world cystalization challenges.

Comprehensive Solutions

Automated systems for solubility and metastable zone width (MSZW) measurements, enhancing process development and scale-up.

Advanced Turbidity Sensing Technology

Utilize turbidity sensors to monitor crystallisation kinetics in real-time, enabling precise control over nucleation and growth phases.

Versatile Experimental Configurations

Configure systems for batch, semi-batch, or continuous crystallisation processes, accommodating a wide range of experimental setups.

Data-Driven Process Optimization

Collect and analyze comprehensive data to optimize crystallisation conditions, improving yield, purity, and reproducibility.

Supports Diverse Applications

Customized systems to meet specific needs in pharmaceuticals, chemicals, and other industries, ensuring alignment with unique process requirements.

Seamless Automation

Integrated advanced software platform to automate experiments, monitor real-time data, and facilitate efficient workflow management.

CrystalSCAN Product Icon

CrystalSCAN | Parallel Crystallization Monitoring Platform

For determination of solubility curves and the MSZW of multiple samples, and optimization…

CrystalEYES Product Icon

CrystalEYES | Crystallization Monitoring Sensor

Detect the dissolution points and nucleation points of solutions during crystallization…

What our Customers Say

Real feedback from industry leaders

I use a H.E.L. turbidity probe plus temperature probe for the determination of metastable zone widths and latent/induction time measurements in the study of crystallisation behaviour. The system is easy to use and very robust and records faithfully all the happenings. Even if one manages to do silly things, the data is still there and recoverable. The probes are neat and so can be used in small ve...

University of Southampton – Southampton, England

Relevant Publications for Crystallization

Published research and studies supporting our technology

Supersolubility and solubility of lithium phosphate in sodium carbonate solution
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Development of a Calibration Model for Real-Time Solute Concentration Monitoring during Crystallization of Ceritinib Using Raman Spectroscopy and In-Line Process Microscopy
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Crystallization Behavior of Ceritinib: Characterization and Optimization Strategies
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L-Tyrosine production by recombinantβ€―Escherichia coli: Fermentation optimization and recovery
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Evaluation of the difficulty of crystallization of organic compounds using the critical supersaturation ratio (Sc)
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Cooling crystallization of aluminum sulfate in pure water
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Solubility, Metastable Zone Width, and Nucleation Kinetics of Boric Acid in the NaCl–KCl–CaCl2–H2O System
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Solubility of 1,1-diamino-2,2-dinitroethylene in different pure solvents and binary mixtures (dimethyl sulfoxide + water) and (N,N-dimethylformamide + water) at different temperatures
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Study of the Solubility, Supersolubility and Metastable Zone Width of Li2CO3 in the LiClβˆ’NaClβˆ’KClβˆ’Na2SO4 System from 293.15 to 353.15K
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Determination of Nucleation Kinetics from the Induction Time of 1,1-Diamino-2,2-Dinitroethylene (FOX-7) in DMSO/Water
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Metastable Zone Widths, Conformational Multiplicity, and Seeding
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Effect of silica nanoparticles to prevent calcium carbonate scaling using an in situ turbidimetre
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Efficient Solvent Selection Approach for High Solubility of Active Phytochemicals: Application for the Extraction of an Antimalarial Compound from Medicinal Plant
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Solid-liquid equilibrium for proteins in solutions with an unconventional salt (ammonium carbamate): Phase behavior analysis
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The temperature dependence of the pre-exponential factor and interfacial energy for aqueous glycine solutions based on the metastable zone width data
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Determination of Solubility and Nucleation Kinetics of Valnemulin Hydrochloride Solvate
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A practical guide to the measurement of turbidity curves of cooling crystallisations from solution
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Effects of Various Inhibitors on the Nucleation of Calcium Oxalate in Synthetic Urine
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Industries and Applications

Supporting a wide range of industries with specialized solutions for crystalization studies.

Pharma, Fine Chemicals, Food/Cooling Crystallization

Pharma, Fine Chemicals, Food/Cooling Crystallization

Control cooling profiles to optimise nucleation and growth, achieving desired crystal size and purity.

Material science, polymers and advanced materials.

Material science, polymers and advanced materials.

Primarily facilitating determination of solubility curves and the metastable zone width (MSZW). They can help…

Production of liquid medication into tablet form

Production of liquid medication into tablet form

Research into solubility of liquids to determine the temperature range over which suitable tablets can…

Separation of chemicals

Separation of chemicals

Crystallization of selected chemicals in order to separate them (by filtration) from other more soluble…

Seeded Crystallization

Seeded Crystallization

Use seed crystals to control growth kinetics and reduce batch variability for consistent product quality.

Reach out to a Specialist

Contact us today to request a quote or learn more about our crystalizaton solutions. We’re here to help you find the right solution.

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