CrystalEYES Featured Image
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CrystalEYES | Crystallization Monitoring Sensor

Easily Determine Solubility…

The need to study crystallization is widespread in the chemical industry due to the importance of solids as the final form of many products. H.E.L’s CrystalEYES makes it easy for chemists to determine the crystallisation and dissolution points of their solutions.

Crystal Eyes monitors and logs temperature, turbidity, and pH. The system includes a choice of probes, signal conditioning electronics, and a compact PC with preloaded software ready to use. H.E.L offers a range of probes for any scale: from a test tube (~2 ml) to a bench-scale (5 L). All probes are available in PEEK, stainless steel, or Hastelloy. Want to work at different scales?- Simply change the probe, no other changes needed to the electronics or software. The data is automatically recorded into .csv format, making it readily importable to Excel, or similar packages for analysis.

Features and Options

CrystalEYES includes:
  • Temperature and turbidity probes were chosen specifically for your application
  • Electronics and PC with data handling software
  • pH monitoring is also available

 

Ease of Use:
  • Insert the probes into your vessel
  • Heat and cool your solution
  • The data is automatically displayed and recorded

 

Data Handling:
  • Real-time data display and capture
  • Data is automatically saved to a data file
  • Data is readily exported to Excel for analysis

The maximum temperature and pressure of the CrystalEYES is 200 oC and MWP is 10 bar at 25 oC

 

Turbidity

The CrystalEYES systems, utilize H.E.L’s proprietary turbidity sensors and WinISO Control software for accurate detection of solubility and recrystallization points. The software detects solubility and recrystallization points from sharp changes in signal and this is displayed graphically in real-time, allowing immediate interpretation.

The probes are simple in design, robust and cost-effective. The design is far more sensitive than standard turbidity and as a result, produces much more accurate results.

A Near-Infrared (NIR) source sends light through the solution and back to a detector via a mirror. Turbidity then can be measured as a function of the light intensity – as particles increase, intensity drops and turbidity increases.

Probes are constructed in hard-wearing Hastelloy for excellent chemical compatibility. The system is compact with the light source and the detector is built-in to each probe and 8 probes can be comfortably operated simultaneously on the H.E.L CrystalSCAN system. At just 5 mm in diameter, the probes can be used with the smallest of vessels.

Publications

The following are a list of some technical publications which highlight the use of the equipment.

Effects of Various Inhibitors on the Nucleation of Calcium Oxalate in Synthetic Urine

Yu-Chao Hsu, Yi-Hsuan Lin, Lie-Ding Shiau

01-Apr-2020

https://doi.org/10.3390/cryst10040333(Subscription or purchase maybe required for full access)

A practical guide to the measurement of turbidity curves of cooling crystallisations from solution

Simon J. Coles ORCID logo and Terence L. Threlfall 

01-Feb-2020

https://doi.org/10.1039/C9CE01622H(Subscription or purchase maybe required for full access)

Determination of Solubility and Nucleation Kinetics of Valnemulin Hydrochloride Solvate

Jinbo Ouyang, Bing Na, Zhirong Liu, Limin Zhou, Hongxun Hao

01-Mar-2019

https://doi.org/10.1007/s10953-019-00861-7(Subscription or purchase maybe required for full access)

The temperature dependence of the pre-exponential factor and interfacial energy for aqueous glycine solutions based on the metastable zone width data

Lie-Ding Shiau

01-May-2018

https://doi.org/10.1016/j.jcrysgro.2018.05.020(Subscription or purchase maybe required for full access)

Solid-liquid equilibrium for proteins in solutions with an unconventional salt (ammonium carbamate): Phase behavior analysis

G. Hirata, P. Filho, E. Miranda

01-Apr-2017

https://doi.org/10.1016/j.fluid.2017.03.031(Subscription or purchase maybe required for full access)

Efficient Solvent Selection Approach for High Solubility of Active Phytochemicals: Application for the Extraction of an Antimalarial Compound from Medicinal Plant

Souhila Laboukhi-Khorsi,†,‡ Kamel Daoud,‡ and Smain Chemat

01-Mar-2017

https://doi.org/10.1021/acssuschemeng.7b00384(Subscription or purchase maybe required for full access)

Effect of silica nanoparticles to prevent calcium carbonate scaling using an in situ turbidimetre

W.N.Al NasseraU.V.ShahbK.NikiforoubP.PetroubJ.Y.Y.Hengb

01-Dec-2015

https://doi.org/10.1016/j.cherd.2015.12.006(Subscription or purchase maybe required for full access)

Metastable Zone Widths, Conformational Multiplicity, and Seeding

Terence L. Threlfall,* Russell W. De’Ath, and Simon J. Coles

01-Feb-2013

https://doi.org/10.1021/op3003486(Subscription or purchase maybe required for full access)

University of Southampton

start quote I use a H.E.L. turbidity probe plus temperature probe for the determination of metastable zone widths and latent/induction time measurements in the study of crystallisation behaviour. The system is easy to use and very robust and records faithfully all the happenings. Even if one manages to do silly things, the data is still there and recoverable. The probes are neat and so can be used in small vessels, an advantage when dealing with valuable compounds. The amount of data that the computer will hold from a run is astonishing. The help from the technical team is always there, so we have been very pleased with our purchase. start quote

University of Southampton – Southampton, England

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