Description
This highly configurable system from the H.E.L product family excels in optimizing process conditions and determining safer reaction conditions. With dual reactor options available, offering more flexibility for applications.
In addition to traditional heat flow calorimetry, the Simular offers power compensation calorimetry allowing operators to skip time-consuming calibration steps and get more conditions screened. The Simular is ideally suited for process safety and scale-up of the most varied and demanding reactions.
Simular Video Demo
Simular Reaction Calorimeter Brochure
Chemical Synthesis Specifications
Chemical Synthesis Brochure
Process Safety and Scale Up Specifications
Overview
Highly Configurable & Flexible System
The Simular Process Development Reaction Calorimeter is a highly configurable and flexible system, designed as part of the H.E.L product family for process safety and chemical synthesis, featuring dual reactor options. Its unique capabilities as a calorimeter and an automated jacketed reactor allow for exceptional versatility in various applications, including adiabatic calorimetry, autocatalysis, and batch and semi-batch reactors.
Optimize Process Conditions
Leveraging the derived thermodynamic and kinetic information of the reaction, the system aims to optimize process conditions, achieving the dual goals of maximizing product yield while minimizing safety hazards. It enables efficient and effective adjustments to key operating parameters by precisely monitoring and controlling the heat flow.
Determine Safer Reaction Conditions
Determining the safer reaction conditions is crucial to ensuring safety during scale-up operations. The system facilitates this by calculating the plant cooling capacity required for maintaining isothermal conditions (Tp) and accurately predicting the maximum temperature the main reaction may reach during a thermal runaway. These calculations are vital in determining the emergency cooling capacity needed for robust scale-up.
Calibration-Free Power Compensation Calorimetry
The Simular Process, Development Reaction Calorimeter, supports both classic heat flow calorimetry and advanced calibration-free power compensation calorimetry. This advanced feature allows users to choose the most appropriate method for their specific reaction requirements, ensuring accurate and reliable measurements for precise process control and optimization.
Features and Options
- Configurable system: dual reactor options
- Two modes: Calibration-free Power Compensation Calorimetry or Heat Flow Calorimetry
- Versatility of use: Calorimeter or automated jacketed reactor
- Safety features: Minimize safety hazards and maximize product yield
| Specification Point |
Simular |
| Typical Applications |
- Process safety
- Process scale-up
- Process development and optimization
|
| Vessel Material |
Glass, 316 Stainless steel, and Hastelloy C276 |
| Vessel Volume |
250 mL to 5L* |
| Dual Vessel |
A dual vessel option is available (typically with a glass, ambient pressure vessel and a metal, high-pressure vessel) including a larger dual frame and switching between reactors |
| Temperature Range |
-80°C to 250°C (dependent on reactor material and circulator)* |
| Pressure Range |
Vacuum to 100 bar (optional pressure – up to 200 bar, depending on reactor volume and material)* |
| Sensor Options |
- Temperature, pressure, pH, turbidity, and other sensors are available.
- Integration of third-party probes is possible, such as in-situ FTIR, particle sizing probes and Raman probes with software integration.
|
| Control & Analysis Software |
- Easy to use, powerful software designed both advanced users and beginners.
- Intelligent automation: Customizable interface with real-time sensor readings, allowing for feedback loops, and reactor parameters based on user preferences.
- User-defined experiment plans covering simple to advanced reactions.
- Common software across H.E.L group process safety product range for ease of use and to save time on training.
|
| Calorimetry Modes |
Isothermal calorimetry:
- Power compensation calorimetry
- Heat flow calorimetry
- Optional: Reflux calorimetry
- Other methodologies:
Isoperibolic calorimetry
|
| Safety Features |
Automatic user-configurable shutdown procedures if a safety condition is exceeded to ensure user safety. |
*Contact your local H.E.L group representative to discuss additional options.
Applications
Reaction Calorimetry
Thermal properties of the desired reaction (1)
The Simular measures the energy evolved in the reaction. Subsequently, this enables you to calculate the plant cooling capacity required to keep the reaction isothermal (Tp).
Thermal runaway of the reaction (2)
In the event of plant failure, it is critical to understand the maximum temperature the main reaction will reach during any subsequent thermal runaway.
The Simular enables the Maximum Temperature of Synthesis Reaction (MTSR) to be calculated from the data of the reaction. Multiple reaction conditions can also be screened to help understand the kinetics of the reaction. From this, it can be assessed whether there will be sufficient time and emergency cooling capacity to deal with the temperature increase.
Minimizing the risk
Hazard assessments may highlight insufficient plant emergency capacity to avert the risk of thermal runaway. The Simular can be used to explore and design safer reaction conditions, thereby facilitating the optimization of safe operations and minimizing process risk.
Publications
The following are a list of some technical publications which highlight the use of the equipment.
F. M. Mahdi, A. P. Shier, I. S. Fragkopoulos, J. Carr, P. Gajjar and F. L. Muller
29-Oct-2022
https://link.springer.com/article/10.1007/s11095-020-02958-x(Subscription or purchase maybe required for full access)
Rajendra Kumar and Anurag Kumar Tiwari
06-Apr-2022
https://journals.pan.pl/Content/124706/PDF/art17_int.pdf(Subscription or purchase maybe required for full access)
Wei Wang , Jiancun Gao , Chenguang Shi, Shengnan Wang, Yujing Li, Xiong Dai, and Tianmeng Jiang
01-Mar-2022
https://doi.org/10.1155/2022/6776179(Subscription or purchase maybe required for full access)
Jiancun Gao, Chenguang Shi, Sisi Liu, Shengnan Wang and Wei Wang
18-Sep-2021
https://link.springer.com/article/10.1007/s10973-021-11052-2(Subscription or purchase maybe required for full access)
Cloudius R. Sagandira and Paul Watts
18-May-2018
https://doi.org/10.1007/s41981-018-0010-9(Subscription or purchase maybe required for full access)
Julie Parker and Katarina Novakovic
30-Sep-2017
https://link.springer.com/article/10.1007/s11144-017-1282-z(Subscription or purchase maybe required for full access)
Julie Parker & Katarina Novakovic
11-Feb-2016
https://doi.org/10.1007/s11144-016-0979-8(Subscription or purchase maybe required for full access)
Lynn Donlon, Julie Parker and Katarina Novakovic
19-Feb-2014
https://doi.org/10.1007/s11144-014-0685-3(Subscription or purchase maybe required for full access)
Alba Pineda-Solano, Lina Saenz-Noval, Subramanya Nayak, Simon Waldram, Maria Papadakic and M. Sam Mannan
05-Nov-2012
https://www.sciencedirect.com/science/article/pii/S0957582012000456(Subscription or purchase maybe required for full access)
Alba Pineda-Solanoa, Lina R.Saenza, Victor Carreto, Maria Papadaki and M. Sam Mannan
05-Sep-2012
https://www.sciencedirect.com/science/article/pii/S0950423012000435(Subscription or purchase maybe required for full access)
Xiaojun Lai, Kevin J. Roberts, Joakim Svensson and Graeme White
03-Feb-2011
https://pubs.rsc.org/en/content/articlelanding/2011/ce/c0ce00786b/(Subscription or purchase maybe required for full access)
Katarina Novakovic,* Ankur Mukherjee, Mark Willis, Allen Wright and Steve Scott
01-Aug-2009
https://doi.org/10.1039/b905444h(Subscription or purchase maybe required for full access)
LijunLiua, Maria Papadaki, Eleni Pontiki, Panagiota Stathi, William J. Rogers and M. Sam Mannan
15-Jun-2009
https://www.sciencedirect.com/science/article/abs/pii/S0304389408015112(Subscription or purchase maybe required for full access)
Lijun Liu, Maria Papadaki, Elen Pontiki, Panagiota Stathi, William J.Rogers and M. Sam Mannan
15-Jun-2009
https://doi.org/10.1016/j.jhazmat.2008.10.023(Subscription or purchase maybe required for full access)
Maria I. Papadaki, Eleni Pontiki, Lijun Liu, William J. Rogers, and M. Sam Mannan
19-May-2009
https://pubs.acs.org/doi/abs/10.1021/je9001366#(Subscription or purchase maybe required for full access)
Thimma Rawalpally, Yaohui Ji, Ashish Shankar, William Edwards, Joshua Allen, Yong Jiang, Thomas P. Cleary, and Michael E. Pierce
15-Oct-2008
https://pubs.acs.org/doi/10.1021/op8001596(Subscription or purchase maybe required for full access)
M. Sheikhzadeh, M. Trifkovic and S.Rohani
01-Mar-2008
https://www.sciencedirect.com/science/article/pii/S0009250907005179(Subscription or purchase maybe required for full access)
M. Trifkovic, M. Sheikhzadeh, and S. Rohani
01-Feb-2008
https://doi.org/10.1021/ie071125g(Subscription or purchase maybe required for full access)
M. Sheikhzadeh M. Trifkovic and S. Rohani
01-Feb-2008
https://www.sciencedirect.com/science/article/pii/S0009250907007993(Subscription or purchase maybe required for full access)
Katarina Novakovic, Mark J. Willis and Allen R. Wright
23-Jan-2008
https://doi.org/10.1007/s10098-007-0136-1(Subscription or purchase maybe required for full access)
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My experience with H.E.L dates since 2005. During these years H.E.L was the provider of the most important lab equipment with the help of which I developed many different API pharmaceutical processes in the companies l worked for including Merck, Pfizer, and Theravance. The versatility of the automated lab reactors (AutoLAB), the ease of use of and the accuracy of the TSu and Simular systems, as well as the flexibility of the PolyBLOCK made my work much easier and accurate. I would like to mention the great relationship I established with the service engineers and the sales people at H.E.L. With their help I was able to customize the software and the hardware of the equipment to our specific needs. This readiness to accommodate each customer’s specific needs gives H.E.L the edge over their competitors and makes them the preferred vendor for pharmaceutical lab equipment. 
