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AutoMATE | Linear, Automated Parallel Synthesis Platform

The AutoMATE is a highly versatile, linear, automated parallel synthesis platform, for use in general chemical synthesis within R&D and process development, as well as more bespoke applications.  As with the PolyBLOCK, the independently controlled reaction zones make AutoMATE especially well-suited for DoE campaigns and the platform’s modular design allows for an easy expansion of capabilities.  In particular, the linear reactor design of the AutoMATE makes it ideal for more demanding applications, such as where multiple inputs and outputs are required.

Application modules that can be added include:

  • Solubility/crystallization monitoring
  • Online calorimetry option
  • Catalyst screening

The platform supports reactor volumes of up to 500 ml per reactor and is equipped with adaptors to support a range of reactor types and sizes, including integration with H.E.L’s catalyst screening CAT reactor blocks.  Additional functionality modules include:

  • Liquid dosing
  • Gas feed
  • Liquid sampling, including integration with the ASU
  • Quick-connect refluxing option
  • Quick-connect inerting solution
  • pH monitoring
Download our Chemical Synthesis Brochure

Features and Options

Temperature Control

  • Ambient to 250 ⁰C (without external cooling).
  • Options to increase the range of -40 ⁰C (circulator dependent) or up to 350 ⁰C.
  • A separate mantle around each reactor allows the temperature to be controlled individually.
  • With a range/difference of over 100 °C between the reactors.

Independent Stirring

  • Indirect agitation with suspended magnetic stirring as standard.
  • Suspended agitation for efficient mixing on small-scale and non-viscous samples.
  • The more spacious ‘suspended’ stirrers are suitable for slurries.
  • Optional Overhead direct agitation for larger vessels.

Intelligent Software Control and Analysis

  • labCONSOL software control enables regular data logging, multi-step recipes, parameter control, and feedback loops. The software adds a responsive intelligence to the AutoMATE 4 system and still delivers an intuitive interface that needs only minimal training to run quickly.

Safety Features

  • Include automatic user-configurable reaction detection and shutdown procedures, to ensure user safety.
  • Automatic hardware and software fail-safes are installed on every system.

Condenser options

  • Easy quick-connect solution for condensing and inerting in larger reactors. Seals allow condensers to be removed without cooling liquid spillage.
  • Also available reflux and inerting block, with adapters for vials, tubes, and reactors


Reactor Options

  • Vessel types are available in Glass, Stainless Steel, or Hastelloy. With reactor volumes up to 500 ml
  • High Pressure and Vacuum Systems available, more details on our high-pressure system can be found on the high-pressure variant
  • Sampling Systems through active pumps, manual dip tubes, automated level control, or multisampling units, like the ASU
  • Reagent Addition through the fully automated liquid and gas feeds as well as volumetric syringe pumps. These solutions can be applied to both high and low-pressure systems.
  • Control Options all relevant inputs can be logged, enabling automated monitoring and, where appropriate, feedback control of the reactor system
  • Sensor Options
    • Temperature, pressure, pH, turbidity, conductivity
    • Integration of third-party probes is possible, such as in-situ FTIR, particle sizing probes, and Raman probes.

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Download our Chemical Synthesis Brochure


The following are a list of some technical publications which highlight the use of the equipment.

Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole

Jacob R. Hauser1,2, Hester A. Beard1,2, Mary E. Bayana1,3, Katherine E. Jolley1,3, Stuart L. Warriner1,2 and Robin S. Bon*2,4


https://doi.org/10.3762/bjoc.12.189(Subscription or purchase maybe required for full access)

Concentration and Separation of Heavy Rare-Earth Metals at Stripping Stage

Olga Cheremisina, Vasiliy Sergeev , Alexander Fedorov * and Daria Alferova


https://doi.org/10.3390/met9121317(Subscription or purchase maybe required for full access)

Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors

A. John Blacker and Katherine E. Jolley


https://doi.org/10.3762/bjoc.11.262(Subscription or purchase maybe required for full access)

Comprehensive kinetic model for the dissolution, reaction, and crystallization processes involved in the synthesis of aspirin

David E. Joiner, Julien Billeter, Mary Ellen P. McNally, Ron M. Hoffman and Paul J. Gemperline


https://doi.org/10.1002/cem.2605(Subscription or purchase maybe required for full access)

Rheological and Hydrogenation Study using a Flow Modified Sponge Ni Catalyst

J. Matt Farmer1*, Norman Marin-Astorga1, Bruce Lacey1, Steve McMahon1, and Chandresh Malde2


https://www.researchgate.net/profile/Matt_Farmer3/publication/293653558_Rheological_and_Hydrogenation_Study_using_a_Flow_Modified_Sponge_Ni_Catalyst/links/56ba4bc608ae6a0040adeb24/Rheological-and-Hydrogenation-Study-using-a-Flow-Modified-Sponge-Ni-Catalyst.pdf(Subscription or purchase maybe required for full access)

Mixed-level supersaturated design application to a robustness study on an organic synthesis

Alice Croguennoc, Marc Frédéric, Magalie Claeys-Bruno, Roger Phan-Tan-Luu, Michelle Sergent


https://doi.org/10.1016/j.chemolab.2012.01.005(Subscription or purchase maybe required for full access)

A novel technique combining high-resolution synchrotron x-ray microtomography and x-ray diffraction for characterization of micro particulates

David R Merrifield1, Vasuki Ramachandran1, Kevin J Roberts1, Wesley Armour2, Danny Axford2, Mark Basham2, Thomas Connolley2, Gwyndaf Evans2, Katherine E McAuley2, Robin L Owen


http://dx.doi.org/10.1088/0957-0233/22/11/115703(Subscription or purchase maybe required for full access)

Crystal Product Engineering in the Seeded Cooling Crystallization of Adipic Acid from Aqueous Solution

O. Narducci,† A. G. Jones,*,† and E. Kougoulos‡


https://doi.org/10.1021/op200029h(Subscription or purchase maybe required for full access)

Oligomerisation of linear 1-olefins using a chlorogallate(III) ionic liquid

Martin P. Atkins 1 , Kenneth R. Seddon 2 , and Małgorzata Swadźba-Kwaśny 2


https://doi.org/10.1351/PAC-CON-10-12-03(Subscription or purchase maybe required for full access)

Investigation of pH Effect on Hydrogenation Reaction of Dextrose to Sorbitol using a Mo promoted Sponge Ni catalyst

J. Matt Farmer*, Steven L. McMahon, and Bruce M. Lacey


http://nacatsoc.org/21nam/data/papers/Paper2250.pdf(Subscription or purchase maybe required for full access)

Deactivation and regeneration of ruthenium on silica in the liquid-phase hydrogenation of butan-2-one

Haresh G. Manyar Daniel Weber Helen Daly Jillian M. Thompson David W. Rooney Lynn F. Gladden E. Hugh Stitt J. Jose Delgado Serafin Bernal Christopher Hardacre


https://doi.org/10.1016/j.jcat.2009.04.013(Subscription or purchase maybe required for full access)

Study of System Thermodynamics and the Feasibility of Chiral Resolution of the Polymorphic System of Malic Acid Enantiomers and Its Partial Solid Solutions

Henning Kaemmerer,*,† Heike Lorenz,‡ Simon N. Black,§ and Andreas Seidel-Morgenstern


https://doi.org/10.1021/cg8010508(Subscription or purchase maybe required for full access)

Development of Scaffold Synthesis for the Preparation of New Insulin-Like Growth Factor 1 Receptor Inhibitors

Ilaria Candiani, Germano D’Arasmo,* Franco Heidempergher, and Attilio Tomasi


https://doi.org/10.1021/op8002536(Subscription or purchase maybe required for full access)

Polymorph and Particle Size Control of PPAR Compounds PF00287586 and AG035029

Billie J. Kline,* James Saenz, Nebojsˇa Stankovic ́, and Mark B. Mitchell


https://doi.org/10.1021/op050176r(Subscription or purchase maybe required for full access)

Thermal Hazards of the Vilsmeier−Haack Reaction on N,N-Dimethylaniline

Marcus Bollyn


https://doi.org/10.1021/op0580116(Subscription or purchase maybe required for full access)

Scale-Up of a Vilsmeier Formylation Reaction:  Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory

Ulrich C. Dyer, David A. Henderson, Mark B. Mitchell, and Peter D. Tiffin


https://doi.org/10.1021/op0155211(Subscription or purchase maybe required for full access)