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PolyBLOCK | Compact Automated Parallel Synthesis Platform
Key Features
– 4 or 8 Independent reaction zones
–Independent temperature control (100 °C difference between zones, temperature range of -40 °C to +200 °C)
– Independent agitation control (250 to 1500 rpm, suspended mechanical or overhead stirring available)
– Small footprint – no larger than a typical laboratory notebook
– Use any combination of reaction vessels on one platform
– Intuitive control software with a choice of interfaces
Designed to maximize your laboratory’s productivity, parallel synthesis technologies with PolyBLOCK is an easy-to-use, flexible, and compact multi-reactor system.
With either four (PolyBLOCK 4) or eight (PolyBLOCK 8) independently controlled and monitored zones, PolyBLOCK 4 offers working volumes of up to 500 ml and PolyBLOCK 8 up to 120 ml. Reactor options range from 1 ml HPLC vials to round or flat-bottom flasks up to 250 ml and custom reaction vessels up to 500 ml.
Agitation in each zone is independently controlled and temperature monitoring and control is offered with either reactor and/or zone temperature.
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Publications
The following are a list of some technical publications which highlight the use of the equipment.
Structural analysis of metastable pharmaceutical loratadine form II, by 3D electron diffraction and DFT+D energy minimisation
Grahame R. Woollam, *a Partha P. Das, *b Enrico Mugnaioli, c Iryna Andrusenko, c Athanassios S. Galanis,b Jacco van de Streek, d Stavros Nicolopoulos,b Mauro Gemmi c and Trixie Wagnere
01-Oct-2020
https://doi.org/10.1039/D0CE01216E(Subscription or purchase maybe required for full access)
Rapid synthesis of sodium-rich Prussian white for Sodium-ion battery via a bottom-up approach
Yuming Xi Yangcheng Lu
01-Aug-2020
https://doi.org/10.1016/j.cej.2020.126688(Subscription or purchase maybe required for full access)
Tailoring morphology and bulk density of magnesium ethoxide particles by adding n-hexane and silicone oil
Zhou Lan, Yangcheng Lu
01-Apr-2020
https://doi.org/10.1016/j.partic.2020.02.002(Subscription or purchase maybe required for full access)
Enantioselective Synthesis of a γ-Secretase Modulator via Vinylogous Dynamic Kinetic Resolution
Neil A. Strotman,* Antonio Ramirez, Eric M. Simmons, Omid Soltani, Andrew T. Parsons, Yu Fan, James R. Sawyer, Thorsten Rosner, Jacob M. Janey, Kristy Tran, Jun Li, Thomas E. La Cruz,Charles Pathirana, Alicia T. Ng, and Joerg Deerberg
13-Aug-2018
https://doi.org/10.1021/acs.joc.8b01734(Subscription or purchase maybe required for full access)
Formation mechanism of aroma compounds in a glutathione-glucose reaction with fat or oxidized fat
J. Zhao, T. Wang, J. Xie, Q. Xiao, J. Cheng, F. Chen, S. Wang and B. Sun,
01-Jul-2018
https://doi.org/10.1016/j.foodchem.2018.07.106(Subscription or purchase maybe required for full access)
Influence of Process Parameters on the Heterogeneous Nucleation of Active Pharmaceutical Ingredients onto Excipients
R. Arribas Bueno, C. Crowley, B. Hodnett, S. Hudson and P. Davern, Org. Process. Res. Dev., 2017, 21, 559-570.
01-Mar-2017
https://doi.org/10.1021/acs.oprd.6b00425(Subscription or purchase maybe required for full access)
Synthesis, characterization and performance of bifunctional catalysts for the synthesis of menthol from citronellal
J. Dam, A. Ramanathan, K. Djanashvili, F. Kapteijn and U. Hanefeld, RSC Adv., 2017, 7, 12041-12053.
20-Feb-2017
https://doi.org/10.1039/C6RA25931F(Subscription or purchase maybe required for full access)
One-pot combination of enzyme and Pd nanoparticle catalysis for the synthesis of enantiomerically pure 1,2-amino alcohols
J. Schrittwieser, F. Coccia, S. Kara, B. Grischek, W. Kroutil, N. d'Alessandro and F. Hollmann, Green Chem., 2013, 15, 3318.
01-Sep-2013
https://doi.org/10.1039/C3GC41666F(Subscription or purchase maybe required for full access)
Use of food-grade proteases to recover umami protein–peptide mixtures from rice middlings
Lucia Bagnasco, Valeria M.Pappalardo, Andrea Meregaglia, Thammarat Kaewmanee, Daniela Ubiali, Giovanna Speranzabe. M. Elisabetta Cosulich
01-Jan-2013
https://doi.org/10.1016/j.foodres.2012.11.007(Subscription or purchase maybe required for full access)
Investigation of the Solid-State Polymorphic Transformations of Piracetam
Anthony Maher,*,† Colin C. Seaton,† Sarah Hudson,†,‡ Denise M. Croker,† Åke C. Rasmuson,† and Benjamin K. Hodnett†
05-Nov-2012
https://doi.org/10.1021/cg301418c(Subscription or purchase maybe required for full access)
Effects of Different Organic Acids on Solubility and Metastable Zone Width of Zinc Lactate
Xiangyang Zhang Gang Qian Xinggui Zhou*
27-Sep-2012
https://doi.org/10.1021/je3006453(Subscription or purchase maybe required for full access)
Solid−Liquid Equilibrium of D- and L-Tartaric Acid and Their Importance for Enantioseparation
Xiaofang Wang,† Xiangyang Zhang,† Simon Black,‡ Leping Dang,*,† and Hongyuan Wei†
11-May-2012
https://doi.org/10.1021/je300170y(Subscription or purchase maybe required for full access)
Mixed-level supersaturated design application to a robustness study on an organic synthesis
Alice Croguennoc, Marc Frédéric, Magalie Claeys-Bruno, Roger Phan-Tan-Luu, Michelle Sergent
01-Apr-2012
https://doi.org/10.1016/j.chemolab.2012.01.005(Subscription or purchase maybe required for full access)
Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram
Denise M. Croker,*,†,§ Michael E. Foreman,†,‡ Bridget N. Hogan,†,§ Nuala M. Maguire,†,‡ Curtis J. Elcoate,†,‡ Benjamin K. Hodnett,†,§ Anita R. Maguire,†,∥ Åke C. Rasmuson,†,§ and Simon E. Lawrence†,‡
15-Dec-2011
https://doi.org/10.1021/cg201300e(Subscription or purchase maybe required for full access)
Nucleation kinetics of paracetamol–ethanol solutions from metastable zone widths
Niall A.Mitchell, Patrick J.Frawley
01-Jun-2010
https://doi.org/10.1016/j.jcrysgro.2010.05.043(Subscription or purchase maybe required for full access)
