Flow and Batch Reactor Systems
H.E.L has a broad range of products that are used for many different applications. Our equipment has been used in many cutting-edge studies and scientific breakthroughs. Here is a selection of publications that feature our products and have been organized into application area.
Click the links to the left to direct you to the publications relating to your chosen application area:
Development of a Calibration Model for Real-Time Solute Concentration Monitoring during Crystallization of Ceritinib Using Raman Spectroscopy and In-Line Process Microscopy
Author(s): Matea Gavran, Željka Ujević Andrijić, Nenad Bolf, Nikola Rimac, Josip Sacher and Damir Šahnić
Date: 13/12/2023
Product(s) used
Crystallization Behavior of Ceritinib: Characterization and Optimization Strategies
Author(s): Iva Zokić and Jasna Prlić Kardum
Date: 25/08/2023
Product(s) used
PdCu single atom alloys supported on alumina for the selective hydrogenation of furfural
Author(s): Mohammed J. Islam, Marta Granollers Mesa, Amin Osatiashtiani, Jinesh C. Manayil, Mark A. Isaacs, Martin J. Taylor, Sotirios Tsatsos, Georgios Kyriakou
Date: 15/12/2021
Product(s) used
Production of ethyl lactate by activated carbon-supported Sn and Zn oxide catalysts utilizing lignocellulosic side streams
Author(s): Riikka Kupila, Katja Lappalainen, Tao Hu, Anne Heponiemi, Davide Bergna, Ulla Lassi
Date: 01/08/2021
Product(s) used
Lignin-based activated carbon-supported metal oxide catalysts in lactic acid production from glucose
Author(s): Riikka Kupila, Katja Lappalainen, Tao Hu, Anne Heponiemi, Davide Bergna, Ulla Lassi
Date: 01/02/2021
Product(s) used
The effect of metal precursor on copper phase dispersion and nanoparticle formation for the catalytic transformations of furfural
Author(s): Mohammed J. Islam, Marta Granollers Mesa, Amin Osatiashtiani, Martin J. Taylor, Jinesh C. Manayil, Christopher M. A. Parlett, Mark A. Isaacs, Georgios Kyriakou
Date: 01/09/2020
Product(s) used
Evaluation and Screening of Spherical Pd/C for Use as a Catalyst in Pharmaceutical-Scale Continuous Hydrogenations
Author(s): Eneritz Fernandez-Puertas, Andrew J. Robinson, Hannah Robinson, Shainthavaan Sathiyalingam, Heather Stubbs, and Lee J. Edwards
Date: 01/06/2020
Product(s) used
Ruthenium Catalyzed Direct Asymmetric Reductive Amination of Simple Aliphatic Ketones Using Ammonium Iodide and Hydrogen
Author(s): Dr. Tamal Ghosh, Dr. Martin Ernst, Prof. Dr. A. Stephen K. Hashmi, Dr. Thomas Schaub
Date: 01/06/2020
Product(s) used
Evaluation of Sponge Metal Catalysts in a Trickle Bed Reactor for the Continuous Hydrogenation of an Aliphatic Nitro Intermediate
Author(s): Antonella Carangio, Lee J. Edwards, Eneritz Fernandez-Puertas, Jerome F. Hayes, Maciej M. Kucharski, Graham W. Rutherford, Katherine M. P. Wheelhouse, and Glynn D. Williams
Date: 01/01/2020
Product(s) used
Continuous Flow Synthesis. A Pharma Perspective
Author(s): Laia Malet-Sanz and Flavien Susanne
Date: 01/01/2020
Product(s) used
Platinum-Based Heterogeneous Catalysts for Nitrile Synthesis via Aerobic Oxidative Coupling of Alcohols and Ammonia
Author(s): Yuliya Preger, Thatcher W. Root and Shannon S. Stahl
Date: 01/06/2018
Product(s) used
Flow fine synthesis with heterogeneous catalyst
Author(s): Koichiro Masuda, Tomohiro Ichitsuka, Nagatoshi Koumura, Kazuhiko Sato, Shū Kobayashi
Date: 01/04/2018
Product(s) used
High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine
Author(s): Eric Yu‡ORCID Logo, Hari P. R. Mangunuru‡ORCID Logo, Nakul S. TelangORCID Logo, Caleb J. Kong, Jenson Verghese, Stanley E. Gilliland IIIORCID Logo, Saeed Ahmad, Raymond N. Dominey and B. Frank Gupton
Date: 01/03/2018
Product(s) used
Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol
Author(s): Katharina Plasch, Gerhard Hofer, Walter Keller, Sam Hay, Derren J. Heyes, Alexander Dennig, Silvia M. Glueck and Kurt Faber
Date: 01/03/2018
Product(s) used
Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
Author(s): https://doi.org/10.1021/acssuschemeng.6b00287
Date: 01/03/2016
Product(s) used
Enantiopure Narrow Bite-Angle P–OP Ligands: Synthesis and Catalytic Performance in Asymmetric Hydroformylations and Hydrogenations
Author(s): Dr. Héctor Fernández-Pérez,Dr. Jordi Benet-Buchholz,Prof. Dr. Anton Vidal-Ferran
Date: 21/10/2014
Product(s) used
Process Intensification for the Continuous Flow Hydrogenation of Ethyl Nicotinate
Author(s): Takashi Ouchi,†,‡ Claudio Battilocchio,† Joel M. Hawkins,§ and Steven V. Ley
Date: 01/07/2014
Product(s) used
Adsorption of dimethyl ether (DME) on zeolite molecular sieves
Author(s): Jai B.LadYassir T.Makkawi
Date: 01/07/2014
Product(s) used
Direct synthesis of formic acid from carbon dioxide by hydrogenation in acidic media
Author(s): Séverine Moret, Paul J. Dyson & Gábor Laurenczy
Date: 01/06/2014
Product(s) used
High-throughput screening of monometallic catalysts for aqueous-phase hydrogenation of biomass-derived oxygenates
Author(s): Jechan Lee, Ye Xu, George W. Huber
Date: 01/03/2013
Product(s) used