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BioXplorer 100 | bench-top, parallel 8 bioreactor platform
The BioXplorer 100 is a multi-bioreactor system designed for the optimization of aerobic fermentations. With a working volume as low as 50 ml, the BioXplorer 100 allows for low-working volume processes. The design of the bioreactor’s lid enables customizable configurations, choosing from a wide range of probes and feeds. Controlled by WinISO, BioXplorer is designed to be a fully automatized system.
Overview
Customizable configurations
The BioXplorer 100 features 8 configurable bioreactors, allowing working volumes ranging from 50-150ml. The reactors can be controlled independently or in parallel with a range of probe/sensor configurations available. The system’s modular design allows precise additions of liquids and gases, controlled by up to four sets of eight peristaltic pumps and up to two sets of mass flow controllers.
Optimized solutions for a range of applications
The BioXplorer 100 is optimized for aerobic fermentation and optimal growth. The highly configurable system allows more in-depth process insights and comprehensive data, enabling you to understand your processes better. A huge advantage of the BioXplorer 100 is the increased productivity from the eight parallel reactors, as they simultaneously allow the screening and high throughput of multiple processes. Paired with WinISO, data acquisition in real-time can be used for monitoring the fermentation, and processes can be controlled live through the design of feedback loops.
Flexibility and control
BioXplorer 100 is equipped with a highly customizable range of sensors optimized for the process, allowing for the acquisition of high-throughput data in real-time. BioXplorer 100 is controlled by H.E.L’s WinISO, allowing for strict control of the parameters of the bioprocess. The automatization of processes based on on-line measurements allows for response to changes in the bioreactor through feedback loops.
Compact Parallel Bioreactors
Space and cost-efficient, the BioXplorer 100’s small bioreactors allow up to eight parallel bioprocesses to be run in a system with a small overall footprint. In contrast, the system’s low working volume (50 – 150 ml) minimizes reagent costs and fermentation times. Although small in size, the bioreactors have been designed to be easy to use and for flexibility in sensor configuration to allow real-time data collection in real bioreactor settings. The BioXplorer 100 offers an intelligent solution to overcome bioprocessing challenges.
Technical Literature
The following is a list of supporting Technical Literature.
Application of the INFOGEST Protocol Using the BioXplorer 100 for Automated Digestion Simulation
The use of a H.E.L BioXplorer in fermentations of Cupriavidus necator H16 at elevated pressure using CO2 as the sole carbon source
Publications
The following are a list of some technical publications which highlight the use of the equipment.
Optimizing the production of docosahexaenoic fatty acid by Crypthecodinium cohnii and reduction in process cost by using a dark fermentation effluent
Angelina Chalima, Christos Boukouvalas, Vasiliki Oikonomopoulou and Evangelos Topakas
15-Aug-2022
https://www.sciencedirect.com/science/article/pii/S2666821122001053(Subscription or purchase maybe required for full access)
Studying semi-dynamic digestion kinetics of food: Establishing a computer-controlled multireactor approach
S.H.E. Verkempinck, D. Duijsens, D. Michels, J.M. Guevara-Zambrano, M.R. Infantes-Garcia, K. Pälchen, T. Grauwet
01-Jun-2022
https://www.sciencedirect.com/science/article/abs/pii/S0963996922003581(Subscription or purchase maybe required for full access)
Automated Bioprocess Feedback Operation in a High-Throughput Facility via the Integration of a Mobile Robotic Lab Assistant
Lucas Kaspersetz, Saskia Waldburger, M.-Therese Schermeyer, Sebastian L. Riedel, Sebastian Groß, Peter Neubauer and M.-Nicolas Cruz-Bournazou
07-Apr-2022
https://www.frontiersin.org/articles/10.3389/fceng.2022.812140/full(Subscription or purchase maybe required for full access)
In vitro fermentation test bed for evaluation of engineered probiotics in polymicrobial communities
S. Arcidiancono, A.M. Ehrenworth-Breedon, M.S. Goodson, L.A. Doherty, W. Lyon, G. Jimenez, I.G. Pantoja-Feliciano, J.W. Soares
01-May-2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175340/(Subscription or purchase maybe required for full access)
Dietary vitamin K is remodeled by gut microbiota and influences community composition
J.L. Ellis, J. Philip Karl, A.M. Oliverio, X. Fu, J.W. Soares, B.E. Wolfe, C.J. Hernandez, J. B. Mason, S.L. Booth
01-Mar-2021
https://doi.org/10.1080/19490976.2021.1887721(Subscription or purchase maybe required for full access)
Farm in a Lab: Cultivating A Lab-Grown Meat Solution (PhD thesis)
M.Forcier, J.Ganoe, E.Hall, H.Larochelle
01-May-2020
https://digital.wpi.edu/pdfviewer/q811km91m(Subscription or purchase maybe required for full access)
Acute stressor alters inter-species microbial competition for resistantstarch-supplemented medium
Ida Gisela Pantoja-Feliciano, Jason W. Soares, Laurel A. Doherty, J. Philip Karl, Holly L. McClung, Nicholes J. Armstrong, Tobyn A. Branck and Steven Arcidiacono
22-Dec-2018
https://www.tandfonline.com/doi/full/10.1080/19490976.2018.1554962(Subscription or purchase maybe required for full access)
Acute stressor alters inter-species microbial competition for resistant starch-supplemented medium
I.G. Pantoja-Feliciano, J.W. Soares, L.A. Doherty, J. Philip Karl, H.L. McClung, N.J. Armstrong, T.A. Branck, S. Arcidiancono
01-Dec-2018
https://doi.org/10.1080/19490976.2018.1554962(Subscription or purchase maybe required for full access)
Engineering Robust Production Microbes for Large-Scale Cultivation
M.Wehrs, D.Tanjore, T.Eng, J. Lievense, T.R. Pray, A. Mukhopadhyay
01-Feb-2018
https://doi.org/10.1016/j.tim.2019.01.006(Subscription or purchase maybe required for full access)
Acetate-detoxification of wood hydrolysates with alkali tolerant Bacillus sp. as a strategy to enhance the lipid production from Rhodosporidium toruloides
L. Matsakas, K. Novak, J. Enman, P. Christakopoulos, U. Rova
01-Oct-2017
https://doi.org/10.1016/j.biortech.2017.04.002(Subscription or purchase maybe required for full access)
Mixing Time as a Criterion for Scale Translation of Cell-Culture Processes (Magazine)
M. H. Sani, F. Baganz
01-Jan-2016
https://www.researchgate.net/profile/Mohd-Sani/publication/298787880_Mixing_time_as_a_criterion_for_scale_translation_of_cell-culture_processes/links/56eb7a5508ae2a58dc4a32f0/Mixing-time-as-a-criterion-for-scale-translation-of-cell-culture-processes.pdf#page=41(Subscription or purchase maybe required for full access)
Continuous screening system for inhibited enzyme catalysis: A membrane reactor approach
E. Lyagin, A. Drews, S. Bhattacharya, M.B. Ansorge-Schumacher, M. Kraume
01-Aug-2010
https://doi.org/10.1002/biot.201000130(Subscription or purchase maybe required for full access)
Thermal profiling for parallel on-line monitoring of biomass growth in miniature stirred bioreactors
N. K. Gill, M. Appleton , G. J. Lye
01-Apr-2008
https://doi.org/10.1007/s10529-008-9719-0(Subscription or purchase maybe required for full access)
Miniature bioreactors: current practices and future opportunities
F. Baganz and J.L.Betts
01-May-2006
https://doi.org/10.1186/1475-2859-5-21(Subscription or purchase maybe required for full access)
Design and Characterisation of Parallel Miniature Bioreactors for Bioprocess Optimisation and Scale-up
N.K. Gill
01-Nov-2005
https://discovery.ucl.ac.uk/id/eprint/1445974/1/U593299%20redacted.PDF(Subscription or purchase maybe required for full access)
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