BioXplorer 5000 | Lab-scale bioreactor platform
The BioXplorer 5000 bioreactor is ideally suited to drive your cell culture scale-up efficiency while staying on the bench. With culture volumes between 500 ml and 20 L, the BioXplorer 5000 provides fully automated control of your cell culture.
The systems are available either in standard configurations or can be customized to meet your requirements. With our open system architecture and flexible software offering simple upgrade and integration options.
The BioXplorer 5000 range is ideal for:
- Microbial and mammalian cell culture and gas fermentation
- Elevated (high) pressure design optional
- Process development and optimization and scale-up studies
Increase your process knowledge and take advantage of an exhaustive list of standard options and innovative features including automated inventory monitoring, online cell density analysis, and automatic KLa determination. You can also add specific gas feeds to run cultures at elevated pressures, under aerobic or anaerobic conditions, ideal for C1 gas studies.
Download BioXplorer 5000 brochureFeatures
The H.E.L BioXplorer 5000 bioreactor is suitable for a wide range of applications including microbial and mammalian cell cultures with:
- Automated inventory monitoring
- Online cell density analysis
- Choice of reactor sizes and types, including elevated pressure designs (5 bar or 10 bar options)
- Fully automated control of multiple parallel reactors
Software
The H.E.L control software runs the BioXplorer 5000 system, enabling complex, fully automated experiments to run unattended.
This enables:
- Multi reactor control with unlimited step recipe planning. Plans can be changed online at any time without process interruption
- Starting and stopping reactors individually or simultaneously
- The individual reactor temperature and agitation control
- User-defined data-logging with customisable tabular and graphical displays
- Export data functions and integration with in-house electronic lab notebooks and record-keeping systems
- DoE and QbD package integration
More specifically, the software controls a wide range of system features, including:
- Temperature
- Gas feeds, flow and mix
- pH
- Dissolved oxygen
- Redox
- Stirrer speed
- Torque (for viscosity indication)
- Pressure
- Liquid feed rates
- Antifoam and level detection
Publications
The following are a list of some technical publications which highlight the use of the equipment.
Isobutanol production freed from biological limits using synthetic biochemistry
S. Sherkhanov, T.P. Korman, S.Chan, S. Faham, H. Liu, M.R. Sawaya, WT. Hsu, E. Vikram, T. Cheng, J.U. Bowie
01-Dec-2020
https://doi.org/10.1038/s41467-020-18124-1(Subscription or purchase maybe required for full access)