BioXplorer 400XL

Name: BioXplorer 400XL | Expanded Bench-Top, Parallel 8 Bioreactor Platform
Brand: H.E.L Group

Extended parallel bioreactor screening — 8 × 400 mL

Screen and optimise across eight independent 400 mL bioreactors on a single bench-top platform — highly automated and fully customisable to your requirements.

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Parallel reactors

120–400 mL

Working volume

Automated

Control

Real-time

Monitoring

0–130 °C

Temperature

up to 2000 rpm

Agitation

Why choose the BioXplorer 400XL?

Screen at scale

Run eight bioprocesses in parallel at up to 400 mL to accelerate optimisation.

Efficient by design

Modest working volumes reduce media and reagent consumption.

Independent control

Per-reactor pH, DO, temperature and feeding for reproducible data.

Actionable insights

Real-time data and WinISO tools for faster, data-driven decisions.

Specifications

Number of independent parallel bioreactors	8
Bioreactor material	Glass body, stainless steel lid
Total volume	500ml
Working volume	120 – 400 ml
Sterilization	Autoclavable bioreactors (including sensors)
Temperature Range	0 – 130 °C
Temperature resolution	0.1 °C
Stirrer drive	Magnetically driven captive impeller or Overhead agitation (magnetically coupled)
Stirrer speed	Magnetically Driven – 250 – 1500 rpm Overhead Agitation – 20- 2000rpm
Auto re-couple	Magnetically Driven – Yes Overhead Agitation – N/A
Liquid additions with independent control for each bioreactor	Magnetically Driven – 2 as standard, options for up to 2 additional liquid feeds
Gas additions	1 set of 8 mass flow controllers allowing independent control for each reactor as standard, option for 1 additional set
Standard options for MFC calibration	Air, oxygen as option
Gas spargers	1
Exhaust gas	Peltier cooled condenser
pH control	1-way control (2-way control optional)
pH Sensing	0-14
Polarographic DO sensing	Standard
DO control	Gas/liquid flow rate, stirrer speed (Optional)
BioVIS cell-density monitoring	Optional
Tandem off-gas analysis	Optional
Foam/Level detection	Optional
Control PC and software	WinISO control software (pre-installed)

Software

The H.E.L WinISO software runs every reactor with fully independent, automated control — advanced strategies from sensor feedback, time-based profiles or event detection, with real-time logging and .csv export.

Fully customisable, it controls the complete range of process parameters — temperature, stirrer speed, dissolved oxygen, pH, gas flow rates, liquid feed rates and foam & level detection.

Applications

Parallel bioprocess optimisationAerobic fermentationHigh-density cultivationYeast fermentationGas fermentationSustainable aviation fuel

Frequently asked questions

What is the BioXplorer 400XL used for?

An extended eight-reactor bench-top platform for parallel bioprocess optimisation at up to 400 ml working volume — aerobic fermentation, high-density cultivation, yeast and gas fermentation, and SAF development.

Is the system customisable to my process?

Yes. Every BioXplorer 400XL is configured to your requirements — probes, sensors, gas and liquid feeds are all specified around your application. Customisation to the customer’s process is central to H.E.L’s approach.

How many reactors and what working volume?

Eight parallel, independently-controlled bioreactors with working volumes of 120–400 ml (glass body, stainless-steel lid, fully autoclavable including sensors).

What temperature and agitation does it offer?

0 to 130 °C with 0.1 °C resolution, with a choice of magnetic stirring (250–1500 rpm) or overhead agitation (20–2000 rpm).

What does the control software do?

The H.E.L WinISO software gives fully independent control of all eight reactors — automated stirring, gas and liquid additions from sensor feedback, with real-time logging and .csv export.

What monitoring options are available?

pH (0–14) and polarographic dissolved-oxygen sensing as standard; optional BioVIS for online cell-density monitoring and foam/level detection; optional Tandem off-gas analysis for OUR, CPR and RQ.