FlowCAT | A Bench-Top, High Pressure Flow Catalysis Platform

Application Notes:

• Investigating Zinc Oxide-Modified Mordenite as an Effective Catalyst for the Dehydrogenation of Ethanol utilizing the FlowCAT
  • In this study, the H.E.L FlowCAT was used for the development and optimization of a process for the production of acetaldehyde via the dehydrogenation of bioethanol. This is the first stage toward a multistep reaction, taking ethanol to higher-value chemicals. This work was carried out at Durham University by Dr. Russell Taylor and Samuel Raynes, to whom all work is accredited. A full copy of the paper is available from the RSC.
• Investigating a Sponge Metal Catalysts in a Trickle Bed Reactor for Continuous Hydrogenation Inflow
  • In this study, the H.E.L. FlowCAT was used to optimize inflow the reductive hydrogenation of an aliphatic nitro intermediate using a sponge nickel catalyst in a trickle bed reactor. Once optimal conditions were established, 1.2 kg of reagent was successfully reduced via the FlowCAT, with a yield of approximately 90% over a period of 19 hours. This work was carried out by the Chemical Development team and the Clinical Supply Chain team at GSK, to whom all work is accredited.

On-Demand Webinars:

• Flow Chemistry Mini-Symposium 2021: discussing the benefits and challenges of transferring batch into flow process
  • Presentations from flow and catalysis experts, discussing the benefits and challenges of transferring batch into flow process. Following the presentations, the presenters answer questions from the audience.
    • Evaluation of Catalysts in a Trickle Bed Reactor for Continuous Hydrogenations (Lee Edwards | GSK)
    • Cascade Conversion of Biomass Platform Chemicals with Multifunctional Zeolitic Materials (Sam Raynes & Russell Taylor | Durham University)
    • Taming High Energy Photochemical Processes with Flow: Case Studies and Future Perspectives (Joshua-Philip Barham | University of Regensburg)

Blogs:

• Beginner’s Guide to Flow Chemistry
  • For many, a journey into flow chemistry has just begun; therefore, understanding the key aspects of this process is extremely important. Flow chemistry can provide excellent solutions to the chemical industry when utilizing the best and most appropriate technologies to meet demands.
• Exploring the pitfalls of Flow Chemistry – industry and academic insight
  • Recently, H.E.L invited four specialist flow chemistry practitioners to speak at an online symposium on the topic. After the speakers had shared their research and experiences and answered questions from delegates, we took the opportunity to ask some questions of our own. Here, our speakers share their own 'pain points' of working in flow.
• Batch Versus Flow in Pharma: The upsides of continuous chemistry
  • Does today's take-up of flow chemistry in fields such as photochemistry, electrochemistry, and hazardous gas usage mean that the days are numbered for parallel batch reactor testing? We've been talking to leading experts in flow catalysis in pharmaceutical companies to determine how they address this topic.

Technical Literature

The following is a list of supporting Technical Literature.

Investigating Zinc Oxide-Modified Mordenite as an Effective Catalyst for the Dehydrogenation of Ethanol utilizing the FlowCAT

Investigating a Sponge Metal Catalysts in a Trickle Bed Reactor for Continuous Hydrogenation Inflow