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Process Safety and Scale-Up
H.E.L has a broad range of products that are used for many different applications. Our equipment has been used in many cutting-edge studies and scientific breakthroughs. Here is a selection of publications that feature our products and have been organized into application area.
Click the links to the left to direct you to the publications relating to your chosen application area:
81 - 100 of 107 Publications
Development of a Scalable and Safe Procedure for the Production of (3R)-3-(2,3-Dihydro-1-benzofuran-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]- quinolin-9-one, an Intermediate in the Synthesis of PDE-V Inhibitors RWJ387273 (R301249) & RWJ444772 (R290629)
Author(s): Bert Willemsens, Ivan Vervest, Dominic Ormerod, Wim Aelterman, Christine Fannes, Narda Mertens, István E. Markó, and Sebastien Lemaire
Date: 12/07/2006
Product(s) used
Venting of a runaway organic peroxide decomposition in viscous solvents on pilot scale
Author(s): T.J. Snee, L. Cuscó, J.A. Hare, D.C. Kerr & M. Royle
Date: 20/06/2006
Product(s) used
Nitrilase-Catalysed Desymmetrisation of 3-Hydroxyglutaronitrile: Preparation of a Statin Side-Chain Intermediate
Author(s): Sophie Bergeron, David A. Chaplin, John H. Edwards, Brian S. W. Ellis, Catherine L. Hill, Karen Holt-Tiffin, Jonathan R. Knight, Thomas Mahoney, Andrew P. Osborne, and Graham Ruecroft
Date: 01/04/2006
Product(s) used
Critical Assessment of Pharmaceutical Processes A Rationale for Changing the Synthetic Route
Author(s): Mike Butters, David Catterick, Andrew Craig, Alan Curzons, David Dale, Adam Gillmore, Stuart P. Green, Ivan Marziano, Jon-Paul Sherlock, and Wesley White
Date: 08/03/2006
Product(s) used
Towards an Information-Rich Process Development. Part I: Interfacing Experimentation with Qualitative/Semiquantitative Modelling
Author(s): Divine A. Obenndip and Paul N. Sharratt
Date: 08/03/2006
Product(s) used
Polymorph and Particle Size Control of PPAR Compounds PF00287586 and AG035029
Author(s): Billie J. Kline,* James Saenz, Nebojsˇa Stankovic ́, and Mark B. Mitchell
Date: 01/03/2006
Product(s) used
Thermal Hazards of the Vilsmeier−Haack Reaction on N,N-Dimethylaniline
Author(s): Marcus Bollyn
Date: 03/11/2005
Product(s) used
Polymerization Hazard
Author(s): David J. am Ende, David R. Bill, David B. Ripin, and Nancy A. Sage
Date: 14/10/2005
Product(s) used
Modeling the Precipitation of l-Glutamic Acid via Acidification of Monosodium Glutamate
Author(s): A. Borissova, Y. Jammoal, K. H. Javed, X. Lai, T. Mahmud, R. Penchev, K. J. Roberts, and W. Wood
Date: 16/04/2005
Product(s) used
Isothermal reaction calorimetry as a tool for kinetic analysis
Author(s): Andreas Zogg, Francis Stoessel, Ulrich Fischer, Konrad Hungerbühler
Date: 01/09/2004
Product(s) used
Use of reaction calorimetry in thermal risk assessment studies and safe design of batch reactions that can lead to a runaway: application on hydrogen peroxide
Author(s): M. Papadaki
Date: 01/06/2004
Product(s) used
Thermal hazards evaluation for sym-TCB nitration reaction using thermal screening unit (TSU)
Author(s): A. Nandi, V. Sutar & S. Bhattacharyya
Date: 01/06/2004
Product(s) used
On-Line Monitoring of a Crystallization Process
Author(s): Patricia Mougin, Alistair Thomas, Derek Wilkinson, Graeme White, Kevin J. Roberts, Norbert Herrmann, Robert Jack and Richard Tweedie
Date: 16/04/2004
Product(s) used
Different scale experimental techniques to approach the problem of substances generated in the loss of control of chemical systems: a study on ethyl diazoacetate decomposition
Author(s): Katia Marsanich, Federica Barontini, Valerio Cozzani, Alain Creemers, Ronald Kerstend
Date: 01/01/2004
Product(s) used
Calorimetric Approach and Simulation for Scale-Up of a Friedel−Crafts Reaction
Author(s): Lucia Gigante, Angelo Lunghi, Simone Martinelli, Paolo Cardillo, Luca Picello, Roberto Bortolaso, Marco Galvagni, and Renato Rota
Date: 06/11/2003
Product(s) used
A Comparison of Reaction Hazard Screening Techniques
Author(s): D. J. Dale
Date: 31/10/2002
Product(s) used
Thermal Stability: A Review of Methods and Interpretation of Data
Author(s): Stephen M. Rowe
Date: 12/10/2002
Product(s) used
Towards Improved Reaction Runaway Studies: Kinetics of the N-Oxidation of 2-Methylpyridine Using Heat-flow Calorimetry
Author(s): M.Papadaki, V. Stoikou, D. Mantzavinos and J.L.Rodriguez Miranda
Date: 01/07/2002
Product(s) used
Scale-Up of a Vilsmeier Formylation Reaction: Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory
Author(s): Ulrich C. Dyer, David A. Henderson, Mark B. Mitchell, and Peter D. Tiffin
Date: 24/04/2002
Product(s) used
Scale-Up of a Vilsmeier Formylation Reaction: Use of HEL Auto-MATE and Simulation Techniques for Rapid and Safe Transfer to Pilot Plant from Laboratory
Author(s): Ulrich C. Dyer, David A. Henderson, Mark B. Mitchell, and Peter D. Tiffin
Date: 01/04/2002
Product(s) used
