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BioXplorer 400 | bench-top, parallel 4 bioreactor platform
The BioXplorer 400 is equipped with 4 bioreactors with working volumes of up to 400 ml. It is a fantastic tool for parallel bioprocess optimization. The highly configurable nature of their lid expands the testing capability for the bioprocess, choosing which probes to use to characterize in real time the critical parameters for the fermentation. Combined with H.E.L’s WinISO allows for the full automatization of aerobic fermentation.
Overview
Parallel Bioreactor
The BioXplorer 400 has four bioreactors, allowing working volumes from 120 ml to 400ml, each meticulously optimized for aerobic fermentation. These bioreactors form the foundation of your bioprocessing endeavors, allowing you to undertake up to four parallel bioprocesses simultaneously. Whether it’s in-depth experimentation, parallel screening, or accelerated research, the BioXplorer 400 offers many possibilities.
Flexibility & Control
The wide range of probes available with the BioXplorer 400 enables the monitoring of critical parameters for the bioprocess for in-depth characterization. The responsiveness of WinISO allows for the fine control of critical parameters in fermentation through the implementation of automated feedback loops.
BioXplorer 400 is an incredible tool for the characterization and optimization of processes. The customizable configuration of the bioreactors allows for the careful selection of the parameters to track during the fermentation. With a choice of agitation, either magnetic or overhead, which enables a wider range of impellor speeds, allowing cultivation of shear sensitive cells at lower speeds. Higher impellor speeds increase gas transfer for increased cell densities or product yields.
Technical Literature
The following is a list of supporting Technical Literature.
The use of a H.E.L BioXplorer in fermentations of Cupriavidus necator H16 at elevated pressure using CO2 as the sole carbon source
Publications
The following are a list of some technical publications which highlight the use of the equipment.
Cadmium effects on net N 2 O production by the deep-sea isolate Shewanella loihica PV-4
Leonor Pizarro, Catarina Magalhães, C Marisa R Almeida, Maria de Fátima Carvalho, Miguel Semedo
05-Jun-2023
https://academic.oup.com/femsle/article/doi/10.1093/femsle/fnad047/7190621(Subscription or purchase maybe required for full access)
Versioning biological cells for trustworthy cell engineering
Jonathan Tellechea-Luzardo, Leanne Hobbs, Elena Velázquez, Lenka Pelechova, Simon Woods, Víctor de Lorenzo and Natalio Krasnogor
09-Feb-2022
https://www.nature.com/articles/s41467-022-28350-4(Subscription or purchase maybe required for full access)
Harnessing Escherichia coli for bio-based production of formate under pressurized H2 and CO2 gases
M.Roger, T.C. Reed, F. Sargent
01-Jan-2021
https://doi.org/10.1101/2021.01.06.425572(Subscription or purchase maybe required for full access)
Validation and Optimization of a Yeast Dynamic Flux Balance Model using a Parallel Bioreactor System
T. J. Hanly, A.R. Tiernan, M.A. Henson
01-Dec-2013
https://doi.org/10.3182/20131216-3-IN-2044.00002(Subscription or purchase maybe required for full access)
Downloads
The following are a list of available downloads.
