BioXplorer 100 | 8 individually controlled bioreactors

Overview

With working volumes 20 ml to 150 ml, the BioXplorer 100 boosts productivity and enables screening of cell culture conditions.  The modular design and extensive list of options make the BioXplorer 100 adaptable to a wide range of applications, including microbial fermentation, C1 Gas fermentation, and cell culture.  This makes the BioXplorer suitable for process development, Design of Experiment (DoE) studies and essential research.

With fully automated control of eight bioreactors, the BioXplorer 100 supports cell culture working volumes of between 20 ml and 150 ml.  The individual control of each reactor enables the user to run replicate samples, unique conditions, or any combination that your experiment requires.  Multiple systems can be run from the same control PC for extended experiments.

Download BioXplorer 100 brochure

Key Features
- Compact system for optimised use of bench space
- Suitable for robotic integration
- Choice of reactor sizes and and types including elevated pressure design (5 bar or 10 bar options)
- Parallel processing of up to 8 independent reactors. Up to 48 reactors can be controlled from a single PC
-

Bioreactors

We supply a range of different bioreactors compatible with the BioXplorer 100 system.

  • Reusable glass bioreactors are suitable for a wide range of applications at atmospheric pressure
  • Stainless steel reactors for standard or elevated pressure (up to 10 bar / 145 PSI) fermentations
  • Specially designed head plates to accommodate all probes and feeds
  • Working volumes from 20 ml to 150 ml
  • Bioreactor geometry that mimics large scale systems

 

 

The H.E.L control software WinISO runs the BioXplorer 100 system, enabling complex, fully automated experiments to run unattended. This enables:

  • Multi reactor control with unlimited step recipe planning. Plans can be changed online at any time without process interruption
  • Starting and stopping reactors individually or simultaneously
  • User-defined data-logging with customizable tabular and graphical displays
  • Export data functions and integration with in-house electronic lab notebooks and record-keeping systems
  • DoE and QbD package integration

 

More specifically, the software controls a wide range of system features, including:

  • Temperature
  • Gas feeds, flow and mix
  • pH
  • Dissolved oxygen
  • Redox
  • Stirrer speed
  • Torque (for viscosity indication)
  • Pressure
  • Liquid feed rates
  • Antifoam and level detection

Gas Feeds

  • Choose from simple or more sophisticated gas flow control regimes
  • Each bioreactor can be configured with single or multiple mass flow controllers
  • For microbial fermentations, automatic oxygen enrichment is available
  • For cell culture applications CO2 can be used for pH control
  • Ratios of several gases can be mixed and regulated with online feedback from off-gas analytics

 

Liquid Feeds

  • Choice of liquid feeds for standard and pressure applications
  • Highly linear peristaltic pump drives are integrated into standard heads which enable exceptional pH and dosing control as well as a wide operating range
  • Typically, two to four pumps per reactor are supplied but additional pumps can be added as needed
  • Syringe pumps and high-pressure pumps are also available

 

Magnetically Suspended Stirring

  • Ideally suited to small bioreactors with proven performance
  • No shaft seal or moving parts: no sterility issues
  • Excellent magnetic coupling
  • Range of stirrer designs (Marine, Rushton, etc)
  • Speed options of 300 rpm to 1500 rpm or 30 rpm to 200 rpm

pH, Dissolved Oxygen and Redox

  • A wide range of  probes are available to cater for different culture types, reactor sizes and applications
  • All probes are integrated into the WinISO software to allow automated monitoring and feedback loops

 

Off Gas Analysis

  • Tandem off-gas analysis units monitor and control a culture process continuously
  • This enables automatic calculation of oxygen uptake rate (OUR);  carbon dioxide production rate (CPR) and respiration quotient (RQ)

Cell Density and Biomass Monitoring

  • BioVIS enables the online monitoring of cell growth and biomass using optical density, removing  the need for online sampling
  • Track cell growth and understand the processes without taking samples
  • Viable cell density probes can also be integrated

Robot Integration

  • Integration into robotics systems for automatic analysis.

 

 

 

 

Download the BioXplorer brochure for more details

DOWNLOADS

BioXplorer.pdf

Click Here to Download