BioXplorer 100 | bench-top, parallel 8 bioreactor platform
The BioXplorer 100 is a bench-top, parallel 8 bioreactor platform, typically with 125 ml volume reactors. It is typically utilized in:
- Research
- The latter stages of screening / early stages of process development
It has the same design, inputs, and outputs as larger systems, thus facilitating a greater number of investigative variables than a microplate or shake flask, but with an increased number of parallel samples than larger bioreactor systems. This combination of relatively high throughput with high information content enables better decision-making for scale-up and thus can speed up development.
The BioXplorer 100 is available as both a low- and high-pressure variant, enabling access to a wide range of applications ranging from standard gas fermentation and aerobic cultures to facilitating studies into decarbonizing high-pressure C1 gas fermentation.
Resources
Technical Literature:
- The use of a H.E.L BioXplorer in fermentations of Cupriavidus necator H16 at elevated pressure using CO2 as the sole carbon source
- Characterization of the maximum heating performance for the multi-reactor PolyBLOCK 8
- Characterization of the cooling performance for the multi-reactor PolyBLOCK 8
- Characterization of the heating performance for the multi-reactor PolyBLOCK 8
Blogs:
Publications
The following are a list of some technical publications which highlight the use of the equipment.
Optimizing the production of docosahexaenoic fatty acid by Crypthecodinium cohnii and reduction in process cost by using a dark fermentation effluent
Angelina Chalima, Christos Boukouvalas, Vasiliki Oikonomopoulou and Evangelos Topakas
15-Aug-2022
https://www.sciencedirect.com/science/article/pii/S2666821122001053(Subscription or purchase maybe required for full access)
Studying semi-dynamic digestion kinetics of food: Establishing a computer-controlled multireactor approach
S.H.E. Verkempinck, D. Duijsens, D. Michels, J.M. Guevara-Zambrano, M.R. Infantes-Garcia, K. Pälchen, T. Grauwet
01-Jun-2022
https://www.sciencedirect.com/science/article/abs/pii/S0963996922003581(Subscription or purchase maybe required for full access)
Automated Bioprocess Feedback Operation in a High-Throughput Facility via the Integration of a Mobile Robotic Lab Assistant
Lucas Kaspersetz, Saskia Waldburger, M.-Therese Schermeyer, Sebastian L. Riedel, Sebastian Groß, Peter Neubauer and M.-Nicolas Cruz-Bournazou
07-Apr-2022
https://www.frontiersin.org/articles/10.3389/fceng.2022.812140/full(Subscription or purchase maybe required for full access)
In vitro fermentation test bed for evaluation of engineered probiotics in polymicrobial communities
S. Arcidiancono, A.M. Ehrenworth-Breedon, M.S. Goodson, L.A. Doherty, W. Lyon, G. Jimenez, I.G. Pantoja-Feliciano, J.W. Soares
01-May-2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175340/(Subscription or purchase maybe required for full access)
Dietary vitamin K is remodeled by gut microbiota and influences community composition
J.L. Ellis, J. Philip Karl, A.M. Oliverio, X. Fu, J.W. Soares, B.E. Wolfe, C.J. Hernandez, J. B. Mason, S.L. Booth
01-Mar-2021
https://doi.org/10.1080/19490976.2021.1887721(Subscription or purchase maybe required for full access)
Farm in a Lab: Cultivating A Lab-Grown Meat Solution (PhD thesis)
M.Forcier, J.Ganoe, E.Hall, H.Larochelle
01-May-2020
https://web.wpi.edu/Pubs/E-project/Available/E-project-051320-180900/unrestricted/Farm_in_a_Lab_MQP_Report.pdf(Subscription or purchase maybe required for full access)
Acute stressor alters inter-species microbial competition for resistantstarch-supplemented medium
Ida Gisela Pantoja-Feliciano, Jason W. Soares, Laurel A. Doherty, J. Philip Karl, Holly L. McClung, Nicholes J. Armstrong, Tobyn A. Branck and Steven Arcidiacono
22-Dec-2018
https://www.tandfonline.com/doi/full/10.1080/19490976.2018.1554962(Subscription or purchase maybe required for full access)
Acute stressor alters inter-species microbial competition for resistant starch-supplemented medium
I.G. Pantoja-Feliciano, J.W. Soares, L.A. Doherty, J. Philip Karl, H.L. McClung, N.J. Armstrong, T.A. Branck, S. Arcidiancono
01-Dec-2018
https://doi.org/10.1080/19490976.2018.1554962(Subscription or purchase maybe required for full access)
Engineering Robust Production Microbes for Large-Scale Cultivation
M.Wehrs, D.Tanjore, T.Eng, J. Lievense, T.R. Pray, A. Mukhopadhyay
01-Feb-2018
https://doi.org/10.1016/j.tim.2019.01.006(Subscription or purchase maybe required for full access)
Acetate-detoxification of wood hydrolysates with alkali tolerant Bacillus sp. as a strategy to enhance the lipid production from Rhodosporidium toruloides
L. Matsakas, K. Novak, J. Enman, P. Christakopoulos, U. Rova
01-Oct-2017
https://doi.org/10.1016/j.biortech.2017.04.002(Subscription or purchase maybe required for full access)
Mixing Time as a Criterion for Scale Translation of Cell-Culture Processes (Magazine)
M. H. Sani, F. Baganz
01-Jan-2016
https://www.researchgate.net/profile/Mohd-Sani/publication/298787880_Mixing_time_as_a_criterion_for_scale_translation_of_cell-culture_processes/links/56eb7a5508ae2a58dc4a32f0/Mixing-time-as-a-criterion-for-scale-translation-of-cell-culture-processes.pdf#page=41(Subscription or purchase maybe required for full access)
Continuous screening system for inhibited enzyme catalysis: A membrane reactor approach
E. Lyagin, A. Drews, S. Bhattacharya, M.B. Ansorge-Schumacher, M. Kraume
01-Aug-2010
https://doi.org/10.1002/biot.201000130(Subscription or purchase maybe required for full access)
Thermal profiling for parallel on-line monitoring of biomass growth in miniature stirred bioreactors
N. K. Gill, M. Appleton , G. J. Lye
01-Apr-2008
https://doi.org/10.1007/s10529-008-9719-0(Subscription or purchase maybe required for full access)
Miniature bioreactors: current practices and future opportunities
F. Baganz and J.L.Betts
01-May-2006
https://doi.org/10.1186/1475-2859-5-21(Subscription or purchase maybe required for full access)
Design and Characterisation of Parallel Miniature Bioreactors for Bioprocess Optimisation and Scale-up
N.K. Gill
01-Nov-2005
https://discovery.ucl.ac.uk/id/eprint/1445974/1/U593299%20redacted.PDF(Subscription or purchase maybe required for full access)