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BioXplorer 100 | bench-top, parallel 8 bioreactor platform

The BioXplorer 100 is a bench-top, parallel 8 bioreactor platform, typically with 125 ml volume reactors.  It is typically utilized in:

  • Research
  • The latter stages of screening / early stages of process development

It has the same design, inputs, and outputs as larger systems, thus facilitating a greater number of investigative variables than a microplate or shake flask, but with an increased number of parallel samples than larger bioreactor systems. This combination of relatively high throughput with high information content enables better decision-making for scale-up and thus can speed up development.

The BioXplorer 100 is available as both a low- and high-pressure variant, enabling access to a wide range of applications ranging from standard gas fermentation and aerobic cultures to facilitating studies into decarbonizing high-pressure C1 gas fermentation.

Download BioXplorer 100 brochure

Features and Options

Vessel Types and Volumes

  • Reusable glass bioreactors are appropriate for a wide range of applications at atmospheric pressure.
  • All reactors are suitable for autoclaving, with auto-cleavable probes as standard.
  • Uniquely developed head plates to house all feeds and probes.
  • Working volumes ranging from 20 to 100 mL.
  • Bioreactor geometry that mimics production-scale systems.

Temperature Control

  • -50 ⁰C to 250 ⁰C as standard (circulator dependent).
  • Fine temperature control, with fluctuations normally lower than ±0.05 ⁰C

High-Pressure Systems

  • Stainless steel reactors for standard or elevated pressure (up to 10 bar/145 PSI) fermentations.

Sampling Systems

  • Through active pumps, manual dip tubes, automated level control, or multisampling units, like the ASU.

Sensor Options

  • Temperature, pressure, pH, DO, turbidity, conductivity.
  • Optional: Integration of third-party probes, such as in-situ FTIR, particle sizing probes, and Raman probes.

Independent Stirring

  • 250 up to 1500 rpm via suspended magnetic agitation.
  • 0 up to 1500 rpm via overhead stirring.

Reagent Addition

  • Through fully automated liquid and gas feeds as well as volumetric syringe pumps. These solutions can be applied to both high and low-pressure systems.

Control Options

  • All relevant inputs can be logged, enabling automated monitoring and, where appropriate, feedback control of the reactor system

Intelligent Software Control and Analysis

  • The labCONSOL control software from H.E.L operates the BioXplorer 100 system, thereby allowing complicated, completely automated experiments to run without the need to be monitored. This allows:
    • Multi reactor control with unrestricted step recipe planning, where plans can be altered at any time without process interruption
    • User defined data logging with customizable tabular and graphical displays
    • Starting and stopping reactors simultaneously or individually
    • Export data functions and integration with in-house record keeping systems and electronic lab notebooks

Safety Features

  • Include automatic user-configurable reaction monitoring and shutdown procedures, to ensure user safety.

Automatic hardware and software fail-safes are installed on every system.

Resources

Technical Literature:

 

Blogs:

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Downloads

Download BioXplorer 100 brochure

Publications

The following are a list of some technical publications which highlight the use of the equipment.

In vitro fermentation test bed for evaluation of engineered probiotics in polymicrobial communities

S. Arcidiancono, A.M. Ehrenworth-Breedon, M.S. Goodson, L.A. Doherty, W. Lyon, G. Jimenez, I.G. Pantoja-Feliciano, J.W. Soares

01-May-2021

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175340/(Subscription or purchase maybe required for full access)


Dietary vitamin K is remodeled by gut microbiota and influences community composition

J.L. Ellis, J. Philip Karl, A.M. Oliverio, X. Fu, J.W. Soares, B.E. Wolfe, C.J. Hernandez, J. B. Mason, S.L. Booth

01-Mar-2021

https://doi.org/10.1080/19490976.2021.1887721(Subscription or purchase maybe required for full access)


Farm in a Lab: Cultivating A Lab-Grown Meat Solution (PhD thesis)

M.Forcier, J.Ganoe, E.Hall, H.Larochelle

01-May-2020

https://web.wpi.edu/Pubs/E-project/Available/E-project-051320-180900/unrestricted/Farm_in_a_Lab_MQP_Report.pdf(Subscription or purchase maybe required for full access)


Acute stressor alters inter-species microbial competition for resistant starch-supplemented medium

I.G. Pantoja-Feliciano, J.W. Soares, L.A. Doherty, J. Philip Karl, H.L. McClung, N.J. Armstrong, T.A. Branck, S. Arcidiancono

01-Dec-2018

https://doi.org/10.1080/19490976.2018.1554962(Subscription or purchase maybe required for full access)


Acetate-detoxification of wood hydrolysates with alkali tolerant Bacillus sp. as a strategy to enhance the lipid production from Rhodosporidium toruloides

L. Matsakas, K. Novak, J. Enman, P. Christakopoulos, U. Rova

01-Oct-2017

https://doi.org/10.1016/j.biortech.2017.04.002(Subscription or purchase maybe required for full access)


Mixing Time as a Criterion for Scale Translation of Cell-Culture Processes (Magazine)

M. H. Sani, F. Baganz

01-Jan-2016

https://www.researchgate.net/profile/Mohd-Sani/publication/298787880_Mixing_time_as_a_criterion_for_scale_translation_of_cell-culture_processes/links/56eb7a5508ae2a58dc4a32f0/Mixing-time-as-a-criterion-for-scale-translation-of-cell-culture-processes.pdf#page=41(Subscription or purchase maybe required for full access)


Continuous screening system for inhibited enzyme catalysis: A membrane reactor approach

E. Lyagin, A. Drews, S. Bhattacharya, M.B. Ansorge-Schumacher, M. Kraume

01-Aug-2010

https://doi.org/10.1002/biot.201000130(Subscription or purchase maybe required for full access)


Thermal profiling for parallel on-line monitoring of biomass growth in miniature stirred bioreactors

N. K. Gill, M. Appleton , G. J. Lye

01-Apr-2008

https://doi.org/10.1007/s10529-008-9719-0(Subscription or purchase maybe required for full access)


Miniature bioreactors: current practices and future opportunities

F. Baganz and J.L.Betts

01-May-2006

https://doi.org/10.1186/1475-2859-5-21(Subscription or purchase maybe required for full access)


Design and Characterisation of Parallel Miniature Bioreactors for Bioprocess Optimisation and Scale-up

N.K. Gill

01-Nov-2005

https://discovery.ucl.ac.uk/id/eprint/1445974/1/U593299%20redacted.PDF(Subscription or purchase maybe required for full access)