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Process Safety and Scale-Up
H.E.L has a broad range of products that are used for many different applications. Our equipment has been used in many cutting-edge studies and scientific breakthroughs. Here is a selection of publications that feature our products and have been organized into application area.
Click the links to the left to direct you to the publications relating to your chosen application area:
41 - 60 of 68 Publications
The influence of oscillations on product selectivity during the palladiumcatalysed phenylacetylene oxidative carbonylation reaction
Author(s): Katarina Novakovic, Christophe Grosjean, Stephen K. Scott, Andrew Whiting, Mark J. Willis and Allen R. Wrighta
Date: 27/11/2007
Product(s) used
Safety Aspects of a Cyanamide Reaction: Inherent Safe Design through Kinetic Modelling and Adiabatic Testing
Author(s): Wim Dermaut*, Christine Fannes, and Johan Van Thienen
Date: 22/09/2007
Product(s) used
Achieving pH and Qr oscillations in a palladium-catalysed phenylacetylene oxidative carbonylation reaction using an automated reactor system
Author(s): K.Novakovic, C.Grosjean, S.K.Scott, A.Whiting, M.J.Willis, A.R.Wright
Date: 01/02/2007
Product(s) used
Control of Supersaturation in a Semibatch Antisolvent Crystallization Process Using a Fuzzy Logic Controller
Author(s): H. Hojjati, M. Sheikhzadeh, and S. Rohani
Date: 11/01/2007
Product(s) used
Safe and Productive Operation of Homogeneous Semibatch Reactors. II. The Nitration of N-(2-Phenoxyphenyl) Methane Sulfonamide
Author(s): Francesco Maestri, Leonardo Re Dionigi, Renato Rota, Lucia Gigante, Angelo Lunghi, and Paolo Cardillo
Date: 31/10/2006
Product(s) used
Development of a Scalable and Safe Procedure for the Production of (3R)-3-(2,3-Dihydro-1-benzofuran-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]- quinolin-9-one, an Intermediate in the Synthesis of PDE-V Inhibitors RWJ387273 (R301249) & RWJ444772 (R290629)
Author(s): Bert Willemsens, Ivan Vervest, Dominic Ormerod, Wim Aelterman, Christine Fannes, Narda Mertens, István E. Markó, and Sebastien Lemaire
Date: 12/07/2006
Product(s) used
Nitrilase-Catalysed Desymmetrisation of 3-Hydroxyglutaronitrile: Preparation of a Statin Side-Chain Intermediate
Author(s): Sophie Bergeron, David A. Chaplin, John H. Edwards, Brian S. W. Ellis, Catherine L. Hill, Karen Holt-Tiffin, Jonathan R. Knight, Thomas Mahoney, Andrew P. Osborne, and Graham Ruecroft
Date: 01/04/2006
Product(s) used
Critical Assessment of Pharmaceutical Processes A Rationale for Changing the Synthetic Route
Author(s): Mike Butters, David Catterick, Andrew Craig, Alan Curzons, David Dale, Adam Gillmore, Stuart P. Green, Ivan Marziano, Jon-Paul Sherlock, and Wesley White
Date: 08/03/2006
Product(s) used
Towards an Information-Rich Process Development. Part I: Interfacing Experimentation with Qualitative/Semiquantitative Modelling
Author(s): Divine A. Obenndip and Paul N. Sharratt
Date: 08/03/2006
Product(s) used
Polymorph and Particle Size Control of PPAR Compounds PF00287586 and AG035029
Author(s): Billie J. Kline,* James Saenz, Nebojsˇa Stankovic ́, and Mark B. Mitchell
Date: 01/03/2006
Product(s) used
Thermal Hazards of the Vilsmeier−Haack Reaction on N,N-Dimethylaniline
Author(s): Marcus Bollyn
Date: 03/11/2005
Product(s) used
Polymerization Hazard
Author(s): David J. am Ende, David R. Bill, David B. Ripin, and Nancy A. Sage
Date: 14/10/2005
Product(s) used
Modeling the Precipitation of l-Glutamic Acid via Acidification of Monosodium Glutamate
Author(s): A. Borissova, Y. Jammoal, K. H. Javed, X. Lai, T. Mahmud, R. Penchev, K. J. Roberts, and W. Wood
Date: 16/04/2005
Product(s) used
Isothermal reaction calorimetry as a tool for kinetic analysis
Author(s): Andreas Zogg, Francis Stoessel, Ulrich Fischer, Konrad Hungerbühler
Date: 01/09/2004
Product(s) used
Use of reaction calorimetry in thermal risk assessment studies and safe design of batch reactions that can lead to a runaway: application on hydrogen peroxide
Author(s): M. Papadaki
Date: 01/06/2004
Product(s) used
On-Line Monitoring of a Crystallization Process
Author(s): Patricia Mougin, Alistair Thomas, Derek Wilkinson, Graeme White, Kevin J. Roberts, Norbert Herrmann, Robert Jack and Richard Tweedie
Date: 16/04/2004
Product(s) used
Different scale experimental techniques to approach the problem of substances generated in the loss of control of chemical systems: a study on ethyl diazoacetate decomposition
Author(s): Katia Marsanich, Federica Barontini, Valerio Cozzani, Alain Creemers, Ronald Kerstend
Date: 01/01/2004
Product(s) used
Calorimetric Approach and Simulation for Scale-Up of a Friedel−Crafts Reaction
Author(s): Lucia Gigante, Angelo Lunghi, Simone Martinelli, Paolo Cardillo, Luca Picello, Roberto Bortolaso, Marco Galvagni, and Renato Rota
Date: 06/11/2003
Product(s) used
A Comparison of Reaction Hazard Screening Techniques
Author(s): D. J. Dale
Date: 31/10/2002
Product(s) used
Thermal Stability: A Review of Methods and Interpretation of Data
Author(s): Stephen M. Rowe
Date: 12/10/2002
Product(s) used
