H.E.L in Publications

Process Safety and Scale-Up

H.E.L has a broad range of products that are used for many different applications. Our equipment has been used in many cutting-edge studies and scientific breakthroughs. Here is a selection of publications that feature our products and have been organized into application area.

Click the links to the left to direct you to the publications relating to your chosen application area:

41 - 60 of 68 Publications
The influence of oscillations on product selectivity during the palladiumcatalysed phenylacetylene oxidative carbonylation reaction

Author(s): Katarina Novakovic, Christophe Grosjean, Stephen K. Scott, Andrew Whiting, Mark J. Willis and Allen R. Wrighta

Date: 27/11/2007

Product(s) used

Safety Aspects of a Cyanamide Reaction: Inherent Safe Design through Kinetic Modelling and Adiabatic Testing

Author(s): Wim Dermaut*, Christine Fannes, and Johan Van Thienen

Date: 22/09/2007

Product(s) used

Achieving pH and Qr oscillations in a palladium-catalysed phenylacetylene oxidative carbonylation reaction using an automated reactor system

Author(s): K.Novakovic, C.Grosjean, S.K.Scott, A.Whiting, M.J.Willis, A.R.Wright

Date: 01/02/2007

Product(s) used

Control of Supersaturation in a Semibatch Antisolvent Crystallization Process Using a Fuzzy Logic Controller

Author(s): H. Hojjati, M. Sheikhzadeh, and S. Rohani

Date: 11/01/2007

Product(s) used

Safe and Productive Operation of Homogeneous Semibatch Reactors. II. The Nitration of N-(2-Phenoxyphenyl) Methane Sulfonamide

Author(s): Francesco Maestri, Leonardo Re Dionigi, Renato Rota, Lucia Gigante, Angelo Lunghi, and Paolo Cardillo

Date: 31/10/2006

Product(s) used

Development of a Scalable and Safe Procedure for the Production of (3R)-3-(2,3-Dihydro-1-benzofuran-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b]- quinolin-9-one, an Intermediate in the Synthesis of PDE-V Inhibitors RWJ387273 (R301249) & RWJ444772 (R290629)

Author(s): Bert Willemsens, Ivan Vervest, Dominic Ormerod, Wim Aelterman, Christine Fannes, Narda Mertens, István E. Markó, and Sebastien Lemaire

Date: 12/07/2006

Product(s) used

Nitrilase-Catalysed Desymmetrisation of 3-Hydroxyglutaronitrile:  Preparation of a Statin Side-Chain Intermediate

Author(s): Sophie Bergeron, David A. Chaplin, John H. Edwards, Brian S. W. Ellis, Catherine L. Hill, Karen Holt-Tiffin, Jonathan R. Knight, Thomas Mahoney, Andrew P. Osborne, and Graham Ruecroft

Date: 01/04/2006

Product(s) used

Critical Assessment of Pharmaceutical Processes A Rationale for Changing the Synthetic Route

Author(s): Mike Butters, David Catterick, Andrew Craig, Alan Curzons, David Dale, Adam Gillmore, Stuart P. Green, Ivan Marziano, Jon-Paul Sherlock, and Wesley White

Date: 08/03/2006

Product(s) used

Towards an Information-Rich Process Development. Part I: Interfacing Experimentation with Qualitative/Semiquantitative Modelling

Author(s): Divine A. Obenndip and Paul N. Sharratt

Date: 08/03/2006

Product(s) used

Polymorph and Particle Size Control of PPAR Compounds PF00287586 and AG035029

Author(s): Billie J. Kline,* James Saenz, Nebojsˇa Stankovic ́, and Mark B. Mitchell

Date: 01/03/2006

Product(s) used

Thermal Hazards of the Vilsmeier−Haack Reaction on N,N-Dimethylaniline

Author(s): Marcus Bollyn

Date: 03/11/2005

Product(s) used

Polymerization Hazard

Author(s): David J. am Ende, David R. Bill, David B. Ripin, and Nancy A. Sage

Date: 14/10/2005

Product(s) used

Modeling the Precipitation of l-Glutamic Acid via Acidification of Monosodium Glutamate

Author(s): A. Borissova, Y. Jammoal, K. H. Javed, X. Lai, T. Mahmud, R. Penchev, K. J. Roberts, and W. Wood

Date: 16/04/2005

Product(s) used

Isothermal reaction calorimetry as a tool for kinetic analysis

Author(s): Andreas Zogg, Francis Stoessel, Ulrich Fischer, Konrad Hungerbühler

Date: 01/09/2004

Product(s) used

Use of reaction calorimetry in thermal risk assessment studies and safe design of batch reactions that can lead to a runaway: application on hydrogen peroxide

Author(s): M. Papadaki

Date: 01/06/2004

Product(s) used

On-Line Monitoring of a Crystallization Process

Author(s): Patricia Mougin, Alistair Thomas, Derek Wilkinson, Graeme White, Kevin J. Roberts, Norbert Herrmann, Robert Jack and Richard Tweedie

Date: 16/04/2004

Product(s) used

Different scale experimental techniques to approach the problem of substances generated in the loss of control of chemical systems: a study on ethyl diazoacetate decomposition

Author(s): Katia Marsanich, Federica Barontini, Valerio Cozzani, Alain Creemers, Ronald Kerstend

Date: 01/01/2004

Product(s) used

Calorimetric Approach and Simulation for Scale-Up of a Friedel−Crafts Reaction

Author(s): Lucia Gigante, Angelo Lunghi, Simone Martinelli, Paolo Cardillo, Luca Picello, Roberto Bortolaso, Marco Galvagni, and Renato Rota

Date: 06/11/2003

Product(s) used

A Comparison of Reaction Hazard Screening Techniques

Author(s): D. J. Dale

Date: 31/10/2002

Product(s) used

Thermal Stability: A Review of Methods and Interpretation of Data

Author(s): Stephen M. Rowe

Date: 12/10/2002

Product(s) used

41 - 60 of 68 Publications

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